alexa Incidence, Predictive Factors and Prognosis of Tuberculosis among Patients with HIV Infection in Guadeloupe 1988-2009
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Research Article

Incidence, Predictive Factors and Prognosis of Tuberculosis among Patients with HIV Infection in Guadeloupe 1988-2009

Narcisse Elenga1*, Marie-Thérèse Georger-Sow2, Thierry Messiaen3, Isabelle Lamaurie3, Isabelle Favre3, Mathieu Nacher2,4 and Gilles Beaucaire3

1Service de Pédiatrie, Centre Hospitalier de Cayenne, Andrée Rosemon, Rue des Flamboyants, BP 6006-97306 Cayenne Cedex, Guyane Française

2Coordination Régionale VIH (COREVIH) Guadeloupe CHU de Pointe-à-Pitre / Abymes Bâtiment B Ancien Hôpital Ricou 2ème étage BP 465 97159 Pointe-à-Pitre Cedex, Guyane Française

3Service des maladies infectieuses, Guadeloupe CHU de Pointe-à-Pitre / Abymes Bâtiment B Ancien Hôpital Ricou 2ème étage BP465 97159, Pointe-à-Pitre Cedex, Guyane Française

4Centre d’Investigation Clinique Epédémiologie Clinique CIC EC Antilles Guyane CIE 802, Centre Hospitalier de Cayenne, Andrée Rosemon, Rue des Flamboyants, BP 6006-97306 Cayenne Cedex, Guyane Française

*Corresponding Author:
Narcisse Elenga
Service de Pèdiatrie
Centre Hospitalier de Cayenne
Andrèe Rosemon, Rue des Flamboyants
BP 6006-97306 Cayenne Cedex
Guyane Française
Tel: +594 694 978 048
Fax: +594 594 394819
E-mail: [email protected]

Received Date: June 28, 2013; Accepted Date: August 26, 2013; Published Date: August 30, 2013

Citation: Elenga N, Georger-Sow M-T, Messiaen T, Lamaury I, Favre I, et al. (2013) Incidence, Predictive Factors and Prognosis of Tuberculosis among Patients with HIV Infection in Guadeloupe 1988-2009. J AIDS Clin Res 4:235. doi:10.4172/2155-6113.1000235

Copyright: © 2013 Elenga N, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: To determine the incidence, risk factors and prognosis for incident tuberculosis during the follow-up of HIV-infected patients in Guadeloupe. Methods: We conducted a retrospective cohort study using STATA version IC 10.0 (College Station, Texas, USA). Results: A single failure Cox proportional hazards model showed that patients with B CDC category (HR=4.50; 95%CI=1.50-13.60; P=0.007) and patients with C CDC category (HR=138.30; 95%CI=62.80-304.90; P=0.000) were at an increased risk of tuberculosis, whereas patients with low median CD4 count at enrolment ( HR=0.50; 95%CI=0.30- 0.84; P=0.009) and patients treated by ART ( HR=0.45; 95%CI=0.34-0.62; P=0.000) were associated with a low risk of tuberculosis. Conclusion: Our data showed a high incidence of tuberculosis and no socio-economic factors related to tuberculosis among HIV-infected patients. These findings help to effectively guide public health interventions.

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