alexa Increase of IgE Anti-Encephalitozoon cuniculi Antibody Levels in Septic Patients
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

Increase of IgE Anti-Encephalitozoon cuniculi Antibody Levels in Septic Patients

Juan C. Andreu-Ballester1*, Constantino Tormo-Calandín2, Carlos Garcia-Ballesteros3, Victoria Amigo3, Ana Peiró-Gómez4,
Juan Ruiz del Castillo5, Carlos Peñarroja-Otero6, Ferran Ballester7, Soledad Fenoy8, Carmen del Aguila8 and Carmen Cuéllar9
1Head of Research Department, Arnau de Vilanova Hospital, Valencia, Spain
2Professor of Catholic University, School of Medicine, Valencia, Spain
3Hematology Department, Arnau de Vilanova Hospital, Valencia, Spain
4Head of Emergency Department, Arnau de Vilanova Hospital, Valencia, Spain
5Professor in School of Medicine, University of Valencia, Valencia, Spain
6Head of Medicine Department, Casa de la Salud Hospital, Valencia, Spain
7Centre for Public Health Research (CSISP), Valencia, Spain
8Department of Parasitology, San Pablo CEU University, Madrid, Spain
9Department of Parasitology, Faculty of Pharmacy, Complutense University, Madrid, Spain
Corresponding Author : Juan C. Andreu-Ballester M.D. Ph.D.
Research Department, Arnau de Vilanova Hospital
San Clemente 12, 46015, Valencia, Spain
Tel: +34639562863
E-mail: [email protected]
Received June 08, 2014, Accepted August 01, 2014, Published August 08, 2014
Citation: Andreu-Ballestera JC, Tormo-Calandín C, Garcia-Ballesteros C, Amigo V, Peiró-Gómez A, et al. (2014) Increase of IgE Anti-Encephalitozoon cuniculi Antibody Levels in Septic Patients. J Clin Cell Immunol 5:244. doi: 10.4172/2155-9899.1000244
Copyright: © 2014 Andreu-Ballestera JC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Objective: We recently demonstrated that the biggest reduction of T cells in septic patients was produced in the γδ T subset. This depletion was directly proportional to the severity of the septic process, and it was associated with mortality. We hypothesized that microsporidia can harness the deficit of γδ T cells in septic patients to proliferate and contribute to the worsening of the sepsis.

Methods: In this retrospective study, we analyzed anti-Encephalitozoon cuniculi antibody levels in sera from 46 septic patients, and compared them with a similar control group of healthy subjects. As a secondary objective we aimed to relate anti-E. cuniculi antibody levels with αβ and γδ T cells in these patients.

Results: Forty-eight percent of septic patients were positive for IgE anti-E. cuniculi vs 13.0% of healthy subjects (OR: 3.67, CI95% 1.64-8.20, P=0.001). The frequency of αβ and CD56+ γδ T cell subsets decreased in septic patients with positive anti-E. cuniculi IgE antibodies. This decrease was more potent in the CD3+CD56+ γδ T cell subset. The genitourinary focus (urinary tract infections and pyelonephritis) produced a significant higher percentage of anti-E. cuniculi positive cases (11/13 (84.6%), OR=11.0, CI 95% 2.1-58.5, P=0.003).

Conclusion: There was a greater level expression of IgE anti-E. cuniculi in septic patients, reaching almost 50% of positive. The presence of IgE anti-E. cuniculi in septic patients was related to a decrease of αβ and γδ T cells in peripheral blood. This decrease was more potent in the CD3+CD56+ γδ T cell subset. Microsporidia may be heavily involved in the physio-pathological evolution of sepsis.


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