Increase of IgE Anti-Encephalitozoon cuniculi Antibody Levels in Septic Patients
|Juan C. Andreu-Ballester1*, Constantino Tormo-Calandín2, Carlos Garcia-Ballesteros3, Victoria Amigo3, Ana Peiró-Gómez4,
Juan Ruiz del Castillo5, Carlos Peñarroja-Otero6, Ferran Ballester7, Soledad Fenoy8, Carmen del Aguila8 and Carmen Cuéllar9
|1Head of Research Department, Arnau de Vilanova Hospital, Valencia, Spain|
|2Professor of Catholic University, School of Medicine, Valencia, Spain|
|3Hematology Department, Arnau de Vilanova Hospital, Valencia, Spain|
|4Head of Emergency Department, Arnau de Vilanova Hospital, Valencia, Spain|
|5Professor in School of Medicine, University of Valencia, Valencia, Spain|
|6Head of Medicine Department, Casa de la Salud Hospital, Valencia, Spain|
|7Centre for Public Health Research (CSISP), Valencia, Spain|
|8Department of Parasitology, San Pablo CEU University, Madrid, Spain|
|9Department of Parasitology, Faculty of Pharmacy, Complutense University, Madrid, Spain|
|Corresponding Author :||Juan C. Andreu-Ballester M.D. Ph.D.
Research Department, Arnau de Vilanova Hospital
San Clemente 12, 46015, Valencia, Spain
E-mail: [email protected]
|Received June 08, 2014, Accepted August 01, 2014, Published August 08, 2014|
|Citation: Andreu-Ballestera JC, Tormo-Calandín C, Garcia-Ballesteros C, Amigo V, Peiró-Gómez A, et al. (2014) Increase of IgE Anti-Encephalitozoon cuniculi Antibody Levels in Septic Patients. J Clin Cell Immunol 5:244. doi: 10.4172/2155-9899.1000244|
|Copyright: © 2014 Andreu-Ballestera JC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Objective: We recently demonstrated that the biggest reduction of T cells in septic patients was produced in the γδ T subset. This depletion was directly proportional to the severity of the septic process, and it was associated with mortality. We hypothesized that microsporidia can harness the deficit of γδ T cells in septic patients to proliferate and contribute to the worsening of the sepsis.
Methods: In this retrospective study, we analyzed anti-Encephalitozoon cuniculi antibody levels in sera from 46 septic patients, and compared them with a similar control group of healthy subjects. As a secondary objective we aimed to relate anti-E. cuniculi antibody levels with αβ and γδ T cells in these patients.
Results: Forty-eight percent of septic patients were positive for IgE anti-E. cuniculi vs 13.0% of healthy subjects (OR: 3.67, CI95% 1.64-8.20, P=0.001). The frequency of αβ and CD56+ γδ T cell subsets decreased in septic patients with positive anti-E. cuniculi IgE antibodies. This decrease was more potent in the CD3+CD56+ γδ T cell subset. The genitourinary focus (urinary tract infections and pyelonephritis) produced a significant higher percentage of anti-E. cuniculi positive cases (11/13 (84.6%), OR=11.0, CI 95% 2.1-58.5, P=0.003).
Conclusion: There was a greater level expression of IgE anti-E. cuniculi in septic patients, reaching almost 50% of positive. The presence of IgE anti-E. cuniculi in septic patients was related to a decrease of αβ and γδ T cells in peripheral blood. This decrease was more potent in the CD3+CD56+ γδ T cell subset. Microsporidia may be heavily involved in the physio-pathological evolution of sepsis.