Increased Circulating Apoptotic CD31+/CD42b- and Activated CD62E+ Endothelial Micro Particles in Coronary Artery DiseaseShuai-Shuai Hu, Hong-Gang Zhang*, Qiu-Ju Zhang and Rui-Juan Xiu
Institute of Microcirculation, Peking Union Medical College & Chinese Academy of Medical Sciences, Key Lab of Microcirculation, National Health and Family Planning Commission, China
- *Corresponding Author:
- Hong-Gang Zhang
Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China
E-mail: [email protected]
Received Date: July 07, 2014; Accepted Date: July 28, 2014; Published Date: August 03, 2014
Citation: Hu SS, Zhang HG, Zhang QJ, Xiu RJ (2014) Increased Circulating Apoptotic CD31+/CD42b- and Activated CD62E+ Endothelial Micro Particles in Coronary Artery Disease. J Hypertens 3:167. doi:10.4172/2167-1095.1000167
Copyright: © 2014 Hu SS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To examine the phenotypes of endothelial microparticles and platelet microparticles in order to identify a sensitive endothelial microparticle biomarker for monitoring endothelial dysfunction in patients with coronary artery disease, and to examine the mechanisms underlying endothelial dysfunction.
Methods: Thirty-three coronary artery disease patients and 53 healthy subjects were recruited. The absolute numbers of endothelial microparticles and platelet microparticles were measured by flow cytometry, and the clinical characteristics of patients and healthy subjects were recorded. Spearman’s correlation analysis and multiple linear regression analysis were performed to analyse the correlation between endothelial microparticles and platelet microparticles, and between microparticles and clinical data.
Results: There was a significant difference in the number of CD31+/CD42b- endothelial microparticles and CD62E+ endotheial microparticles between patients with coronary artery diease and healthy subjects (p<0.05).
Conclusion: Both endothelial apoptosis and activation play an important role in coronary artery disease, although endothelial apoptosis plays the major role. Endothelial microparticles may be used to monitor endothelial dyfunction in patients with coronary artery disease.