Increased Serum Levels of Oxidative Stress Markers in Patients with Liver Steatosis
|Maria Notarnicola1, Valeria Tutino1, Alberto R Osella2, Caterina Bonfiglio2, Vito Guerra2and Maria Gabriella Caruso1*|
|1Laboratory of Nutritional Biochemistry, Castellana Grotte (BA), Italy|
|2Laboratory of Epidemiology and Biostatistic, National Institute for Digestive Diseases “Saverio de Bellis”, Castellana Grotte (BA), Italy|
|Corresponding Author :||Maria Gabriella Caruso, MD
Laboratory of Nutritional Biochemistry
National Institute for Digestive Diseases “Saverio de Bellis”
Via Turi 27, 70013 Castellana Grotte (BA), Italy
Tel: +39 0804994669
Fax: +39 0804994313
E-mail: [email protected]
|Received August 26, 2013; Accepted September 05, 2013; Published September 13, 2013|
|Citation: Notarnicola M, Tutino V, Osella AR, Bonfiglio C, Guerra V, et al. (2013) Increased Serum Levels of Oxidative Stress Markers in Patients with Liver Steatosis. J Liver 2:127. doi: 10.4172/2167-0889.1000127|
|Copyright: © 2013 Notarnicola M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Background: Several studies have suggested that oxidative stress could play a role in the pathogenesis of nonalcoholic fatty liver disease and more precisely in the transition between simple fatty liver and steatohepatitis.
Aim: This study aims to investigate if circulating levels of oxidative stress markers could be clinically associated with liver steatosis.
Materials and methods: We present data obtained from a subsample of 70 subjects with liver steatosis enrolled by a nutritional trial, called NUTRIEPA study. Serum levels of oxidative stress markers were evaluated by ELISA assay. The diagnosis and the degree of liver steatosis were based on laboratory and ecographic measurements. Statistical methods included Kruskal-Wallis analysis of variance and, Wilcoxon signed-rank or Mann-Whitney test, where appropriate. The χ2 test has been performed to analyze categorical variables.
Results: The subjects with severe or moderate steatosis had significantly higher serum levels of oxidative stress markers compared to subjects without steatosis. Conclusions: Increased serum levels of oxidative stress markers could be considered a marker of moderate and severe liver steatosis.