Increasing Incidence of Primary Aldosteronism in Patients Investigated for Resistant Hypertension: An Observational Study from a Nephrology Unit
Antonio Del Giudice1*, Chiara Di Giorgio2, Giuseppe Di Giorgio1, Rachele Grifa1, Vincenzo Lauriola1, Filomena Miscio1, Matteo Piemontese1, Michele Prencipe1, Antonio Scarlatella1, Andrea Fontana3, Massimiliano Copetti3, Fabio Pellegrini3 and Filippo Aucella1
- *Corresponding Author:
- Antonio Del Giudice
IRCCS Casa Sollievo della Sofferenza Hospital
Department of Medical Sciences
Unit of Nephrology Viale Cappuccini 71013 San Giovanni Rotondo
E-mail: [email protected]
Received Date: March 29, 2012; Accepted Date: April 16, 2012; Published Date: April 18, 2012
Citation: Del Giudice A, Di Giorgio C, Di Giorgio G, Grifa R, Lauriola V, et al. (2012) Increasing Incidence of Primary Aldosteronism in Patients Investigated for Resistant Hypertension: An Observational Study from a Nephrology Unit. J Nephrol Therapeutic S3:007. doi:10.4172/2161-0959.S3-007
Copyright: © 2012 Del Giudice A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Introduction: Primary Aldosteronism (PA) is a secondary form of hypertension characterized by an autonomous and inappropriately high production of aldosterone. Its prevalence is 5-12% and the two main subtypes are the Bilateral Adrenal Hyperplasia (BAH) and the Aldosterone-Producing Adenoma (APA). In this study, we report the results of an evalutation of some patients diagnosed with PA in a Nephrology Unit between 1987-2011.
Patients and methods: As much as 54 patients were screened for PA by measuring Plasma Aldosterone Concentration (PAC) and Plasma Renin Activity (PRA), and by calculating the aldosterone/renin ratio (ARR). Confirmation tests were performed on 47 patients with PAC ≥ 15 ng/dL and ARR ≥ 40. Subtype diagnosing was possible through adrenal CT scan, scintigraphy and adrenal venous sampling.
Results: As much as 31 patients were diagnosed with PA. In 17 of them, the concordance of CT, scintigraphy and AVS findings made it possible to determine the subtype diagnosis: BAH in 10 and APA in 7 patients.
Conclusions: Our results confirm the increasing frequency of diagnosis of PA among patients investigated for resistant hypertension. Early detection of PA in nephrological settings is important because of the relationship between aldosterone and kidney function.