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ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
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Research Article

Indian Hedgehog Protein Levels in Autistic Children: Preliminary Results

Shahid Bashir1,2*, Laila AL-Ayadhi2

1Berenson-Allen Center for Noninvasive Brain Stimulation, Division of Cognitive Neurology, Department of Neurology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA, USA

2KSU-Autism Research and Treatment center, Al-Amodi Autism research chair, Department of physiology, King Saud University, P O Box 2925, Riyadh 11461, Saudi Arabia

*Corresponding Author:
Shahid Bashir
KSU-Autism Research and Treatment center
Al-Amodi Autism research chair
Department of physiology
King Saud University, Saudi Arabia
Tel: T:00966-46-71040
Fax: T:00966-46-71040
E-mail: [email protected]

Received date: September 26, 2012; Accepted date: October 25, 2012; Published date: October 29, 2012

Citation: Bashir S, AL-Ayadhi L (2012) Indian Hedgehog Protein Levels in Autistic Children: Preliminary Results. J Mol Biomark Diagn 3:134. doi:10.4172/2155-9929.1000134

Copyright: © 2012 Bashir S, et al. This is an open-access article distributed underthe terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

The etiology of autism spectrum disorders (ASD) is not well known but recently we reported that the serum levels of sonic hedgehog (SHH) protein and brain-derived neurotrophic factor (BDNF) might be linked to oxidative stress in ASD. We hypothesized that Indian hedgehog (IHH) protein which belongs to SHH family may play a pathological role in the ASD. We studied recently diagnosed patients in early stages of ASD (n=54) and age-matched, cognitively normal, individuals (n=25), using serum levels of IHH protein. We found statistically significantly higher-levels of serum IHH protein in ASD subjects (p=0.001) compared to control subjects. Our findings are the first to report a role of IHH in ASD children, suggesting a possible pathological role-played by IHH in early-stage in ASD. Such measures might constitute an early biomarker for ASD and ultimately offer a target for novel biomarker-based therapeutic interventions.

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