Indian Hedgehog Protein Levels in Autistic Children: Preliminary ResultsShahid Bashir1,2*, Laila AL-Ayadhi2
- *Corresponding Author:
- Shahid Bashir
KSU-Autism Research and Treatment center
Al-Amodi Autism research chair
Department of physiology
King Saud University, Saudi Arabia
E-mail: [email protected]
Received date: September 26, 2012; Accepted date: October 25, 2012; Published date: October 29, 2012
Citation: Bashir S, AL-Ayadhi L (2012) Indian Hedgehog Protein Levels in Autistic Children: Preliminary Results. J Mol Biomark Diagn 3:134. doi:10.4172/2155-9929.1000134
Copyright: © 2012 Bashir S, et al. This is an open-access article distributed underthe terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The etiology of autism spectrum disorders (ASD) is not well known but recently we reported that the serum levels of sonic hedgehog (SHH) protein and brain-derived neurotrophic factor (BDNF) might be linked to oxidative stress in ASD. We hypothesized that Indian hedgehog (IHH) protein which belongs to SHH family may play a pathological role in the ASD. We studied recently diagnosed patients in early stages of ASD (n=54) and age-matched, cognitively normal, individuals (n=25), using serum levels of IHH protein. We found statistically significantly higher-levels of serum IHH protein in ASD subjects (p=0.001) compared to control subjects. Our findings are the first to report a role of IHH in ASD children, suggesting a possible pathological role-played by IHH in early-stage in ASD. Such measures might constitute an early biomarker for ASD and ultimately offer a target for novel biomarker-based therapeutic interventions.