alexa Individual and Combined Effects of Subchronic Exposure of Three Fusarium Toxins (Fumonisin B, Deoxynivalenol and Zearalenone) in Rabbit Bucks
ISSN: 2161-0495

Journal of Clinical Toxicology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Individual and Combined Effects of Subchronic Exposure of Three Fusarium Toxins (Fumonisin B, Deoxynivalenol and Zearalenone) in Rabbit Bucks

Judit Szabó-Fodor1*, Mariam Kachlek1, Sándor Cseh3, Bence Somoskői3, András Szabó1,2, Zsófia Blochné Bodnár2, Gábor Tornyos2, Miklós Mézes4, Krisztián Balogh4, Róbert Glávits5, Dóra Hafner2 and Melinda Kovács1,2

1Faculty of Agricultural and Environmental Sciences, MTA-KE Mycotoxins in the Food Chain Research Group, Kaposvár University, Hungary

2Faculty of Agricultural and Environmental Sciences, Kaposvár University, Hungary

3SZIU Faculty of Veterinary Science, István, Hungary

4SZIU Faculty of Agricultural and Environmental Sciences, Hungary

*Corresponding Author:
Judit Szabó-Fodor
Faculty of Agricultural and Environmental Sciences
MTA-KE Mycotoxins in the Food Chain Research Group
Kaposvár University, Hungary
Tel: +36304303345
E-mail: [email protected]

Received date: July 27, 2015 Accepted date: August 02, 2015 Published date: August 03, 2015

Citation: Szabó-Fodor J, Kachlek K, Cseh S, Somoskoi B, Szabó A, et al. (2015) Individual and Combined Effects of Subchronic Exposure of Three Fusarium Toxins (Fumonisin B, Deoxynivalenol and Zearalenone) in Rabbit Bucks. J Clin Toxicol 5:264. doi:10.4172/2161-0495.1000264

Copyright: © 2015 Szabó-Fodor J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Objective of the study was to determine reproductive toxicity of Fusarium toxins orally at three subchronic doses on adult Pannon White male rabbits. The four treatments were: control (C, toxin-free diet), F (5 mg/kg FB1), DZ (1 mg/kg DON+0.25 mg/kg ZEA), FDZ (5 mg/kg FB1+1 mg/kg DON+0.25 mg/kg ZEA) for 65 days (n=15/treatment). The doses were pre-determined according the EU limits in finished feed for young pig (in the absence of limits for rabbits’ feed; based on the European Commission Recommendation 2006/576/EC and the European Commission Directive 2003/100/EC). The most pronounced effects of the toxins were exerted on the reproductive processes. The ratio of spermatozoa showing progressive forward motility decreased (P<0.05) from 80% to 67% in the FDZ group by day 60. Differences were found between the groups DZ (66.3% ± 23.7) and C (80.2% ± 11.2) in spermatozoa morphology. GnRH treated animals produced less testosterone in FDZ animals, compared to the other three groups (P<0.05). In the comet assay the individual fumonisin treatment resulted in significantly less 0 comets (intact cells), compared to all others. Based on the prevalence of score, lower (P<0.0001) damage was observed in FDZ group, as compared to F and DZ. Among the mycotoxins studied, additive or less than additive effect was found in case of spermatogenesis and sperm cell morphology, synergism in testosterone production, while FB1 acted antagonistically against DON+ZEA in comet assay. All mycotoxins provoked moderate lipid-peroxidation, based on the changes of glutathione concentration, glutathione peroxidase activity and formation of malondialdehyde and conjugated dienes and trienes, and exerted slight genotoxicity based on comet assay, FB1 being antagonistic towards DON+ZEA. In F, DZ and FDZ animals the intensity of spermatogenesis decreased by 43, 31 and 64%, respectively, which was reflected by lack of differentiated spermatozoa, thinning of the germinal epithelium, the appearance of multinuclear giant cells, indicative of the disturbance of meiosis and mitosis of the germinal epithelial cells and in some cases the lack of spermatogonia.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords