alexa Induction of Stress Induced Premature Senescence by Sirtuin-7 Inhibition: A Novel Mechanism for Multi Drug Resistance
ISSN: 1948-5956

Journal of Cancer Science & Therapy
Open Access

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Review Article

Induction of Stress Induced Premature Senescence by Sirtuin-7 Inhibition: A Novel Mechanism for Multi Drug Resistance

Ahmad Aljada1*, Ayman Saleh1and Shaker A Mousa2

1Department of Basic Medical Sciences, King Saud bin Abdulaziz University for Health Sciences & King Abdullah International Medical Research Center (KAIMRC), Riyadh, Kingdom of Saudi Arabia

2Pharmaceutical Research Institute, Albany College of Pharmacy, Albany, NY, USA

*Corresponding Author:
Ahmad Aljada
Department of Basic Medical Sciences
College of Medicine, King Saud bin Abdulaziz University for Health Sciences
King Abdullah International Medical Research Center (KAIMRC)
King Abdulaziz Medical City – Riyadh National Guard Health Affairs, Mail Code: 3127
P. O. Box 22490, Riyadh 11426, Kingdom of Saudi Arabia
Tel: +966(1)2520088 ext. 51041
E-mail: [email protected]

Received date: April 06, 2013; Accepted date: May 10, 2013; Published date: May 12, 2013

Citation: Aljada A, Saleh A, Mousa SA (2013) Induction of Stress Induced Premature Senescence by Sirtuin-7 Inhibition: A Novel Mechanism for Multi Drug Resistance. J Cancer Sci Ther 5:182-189. doi:10.4172/1948-5956.1000204

Copyright: © 2013 Aljada A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Stress-Induced Premature Senescence (SIPS), a senescence-like state achieved as a result of a variety of stresses, is associated with relative inability to undergo apoptosis. Sirtuins are a family of histone deacetylases known primarily for their implication in the aging process; however their role in cancer, an aging associated disease, is still poorly understood. In the present study, we investigated whether alterations in sirtuins expression may be associated with aggressive tumor behavior. We have compared expression profiles of sirtuins between drug sensitive and resistant cancer cells MCF7, SaOS-2, A2780 and HL-60. Expression levels of Sirtuin 1-6 varied among cell lines; however Sirtuin-7 was significantly reduced in all chemoresistant cells tested. Knockdown of Sirt7 expression in human breast MCF7 cell line by RNAi induced senescence-associated β-galactosidase activity, reduced cell proliferation rate, induced drug resistance and increased cell migration, suggesting that this gene may play an active role in regulating cancer cell response to stress. Thus, Sirt7 may represent a compelling target for anti-cancer interventions

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