alexa Induction of Substantial Myocardial Regeneration by an
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Research Article

Induction of Substantial Myocardial Regeneration by an Extract of Chinese Herb Rosa laevigata Michx for Repair of Infarcted Heart

Zhou Feng1, Zhongyu Li3, Sing Li4, Mingfeng Tang2, Xiaoli Lin2, Qiankun Yi2, Zhen Zhou2, Dianbin Li5, Zeli Gao6, Yongming Liu1, Huiyan Qu1, Hua Zhou1* and Ming Li2
1Department of Cardiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine Shanghai, China
2Laboratory of Innovative Medicine, Hong Kong
3Laboratory of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China
4St Francis Xavier College, London, UK
5Department of emergency, Tianshan Chinese Medicine Hospital, Changning District, Shanghai, China
6Department of Gastroenterology, People’s Hospital, Pudong New District, Shanghai, China
Corresponding Author : Hua Zhou
Department of Cardiology, Shuguang Hospital
Shanghai University of Traditional Chinese, Medicine Shanghai, China
Tel: 86-21-20256699
Fax: 86-21-53821650
E-mail: [email protected]
Received February 26, 2014; Accepted April 20, 2014; Published May 05, 2014
Citation: Feng Z, Li Z, Li S, Tang M, Lin X, et al. (2014) Induction of Substantial Myocardial Regeneration by an Extract of Chinese Herb Rosa laevigata Michx for Repair of Infarcted Heart. J Clin Exp Cardiolog 5:312. doi:10.4172/2155-9880.1000312
Copyright: © 2014 Feng Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Coronary Heart Disease (CHD) is the single largest killer out of all diseases in Europe and in the US. Pathologic cardiac ischemia in CHD triggers a succession of events leading to massive destruction and loss of cardiac tissues. Thus, replacement of the damaged cardiac tissues by newly regenerated myocardium would be a therapeutic ideal for pathology modifying treatment of CHD. The aim of this study was to evaluate the ability of an active fraction isolated from Chinese herb Rosa laevigata Michx (aFRLM) in therapeutic cardiomyogenesis through promoting substantial regeneration of cardiac tissues in a Myocardial Infarction (MI) animal model. Our results demonstrated that oral administration of aFRLM to MI animals could significantly improve cardiac functional performance and induce myocardial regeneration replacing the necrosed cardiac tissues in a sub-clinical MI animal model. The property of the aFRLM appears to be entirely novel and may provide a potential therapeutic alternative for MI treatment.

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