Induction of Substantial Myocardial Regeneration by an Extract of Chinese Herb Rosa laevigata Michx for Repair of Infarcted Heart
|Zhou Feng1, Zhongyu Li3, Sing Li4, Mingfeng Tang2, Xiaoli Lin2, Qiankun Yi2, Zhen Zhou2, Dianbin Li5, Zeli Gao6, Yongming Liu1, Huiyan Qu1, Hua Zhou1* and Ming Li2|
|1Department of Cardiology, Shuguang Hospital, Shanghai University of Traditional Chinese Medicine Shanghai, China|
|2Laboratory of Innovative Medicine, Hong Kong|
|3Laboratory of Biotechnology, Dalian Institute of Chemical Physics, Chinese Academy of Sciences, Dalian, China|
|4St Francis Xavier College, London, UK|
|5Department of emergency, Tianshan Chinese Medicine Hospital, Changning District, Shanghai, China|
|6Department of Gastroenterology, People’s Hospital, Pudong New District, Shanghai, China|
|Corresponding Author :||Hua Zhou
Department of Cardiology, Shuguang Hospital
Shanghai University of Traditional Chinese, Medicine Shanghai, China
E-mail: [email protected]
|Received February 26, 2014; Accepted April 20, 2014; Published May 05, 2014|
|Citation: Feng Z, Li Z, Li S, Tang M, Lin X, et al. (2014) Induction of Substantial Myocardial Regeneration by an Extract of Chinese Herb Rosa laevigata Michx for Repair of Infarcted Heart. J Clin Exp Cardiolog 5:312. doi:10.4172/2155-9880.1000312|
|Copyright: © 2014 Feng Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Coronary Heart Disease (CHD) is the single largest killer out of all diseases in Europe and in the US. Pathologic cardiac ischemia in CHD triggers a succession of events leading to massive destruction and loss of cardiac tissues. Thus, replacement of the damaged cardiac tissues by newly regenerated myocardium would be a therapeutic ideal for pathology modifying treatment of CHD.
The aim of this study was to evaluate the ability of an active fraction isolated from Chinese herb Rosa laevigata Michx (aFRLM) in therapeutic cardiomyogenesis through promoting substantial regeneration of cardiac tissues in a Myocardial Infarction (MI) animal model.
Our results demonstrated that oral administration of aFRLM to MI animals could significantly improve cardiac functional performance and induce myocardial regeneration replacing the necrosed cardiac tissues in a sub-clinical MI animal model. The property of the aFRLM appears to be entirely novel and may provide a potential therapeutic alternative for MI treatment.