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ISSN-2155-9929

Journal of Molecular Biomarkers & Diagnosis
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Research Article

Infants and Children with Stage 4 Neuroblastoma Express Significantly Different Levels of Specific Molecular Markers

Stefano Parodi1, Giovanni Erminio2, Barbara Carlini3, Alberto Garaventa4, Paolo D’Angelo5, Riccardo Haupt2, and Maria Valeria Corrias3*

1Clinical Epidemiology, IRCCS San Martino-IST, Largo Benzi 5, 16137 Genoa, Italy

2Epidemiology and Biostatistics Section, Scientific directorate, IRCCS Istituto Giannina Gaslini, Largo Gaslini 5, 16147 Genoa, Italy

3Laboratory of Oncology, and Department of Hematology-Oncology, IRCCS Istituto Giannina Gaslini, Largo Gaslini 5, 16147 Genoa, Italy

4Department of Hematology-Oncology, IRCCS Istituto Giannina Gaslini, Largo Gaslini 5, 16147 Genoa, Italy

5Ospedale dei Bambini, Via Delle Benedettine 1, 90134 Palermo, Italy

*Corresponding Author:
Maria Valeria Corrias
Head Molecular Oncology Laboratory of Oncology
Gaslini Institute Largo Gaslini, 516147 Genoa Italy
Tel: +39 010 5636524
Fax: +39 010 3779820
E-mail: [email protected]

Received date: February 21, 2012; Accepted date: March 29, 2012; Published date: April 05, 2012

Citation: Parodi S, Erminio G, Carlini B, Garaventa A, D’Angelo P, et al. (2012) Infants and Children with Stage 4 Neuroblastoma Express Significantly Different Levels of Specific Molecular Markers. J Mol Biomark Diagn S2:008. doi:10.4172/2155-9929.S2-008

Copyright: © 2012 Parodi S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

In neuroblastoma (NB), age at diagnosis is a strong prognostic factor. Hereby, we evaluated whether patients with metastatic NB below 1 year of age (infants) expressed lower levels of NB-specific molecular markers compared to patients over 1 year (children). Bone marrow (BM) and peripheral blood (PB) samples collected at diagnosis from 54 Italian patients with metastatic NB were analysed by RT-qPCR for TH, PHOX2B and DCX mRNA expression. Statistical analyses were then performed to evaluate the diagnostic performance and the association with other known prognostic factors. In spite of similar levels of morphological BM infiltration, TH, PHOX2B and DCX expression levels in BM and PB samples were significantly lower in stage 4 infants than in children. Between infants with stage 4 and 4S, the former expressed significantly higher levels in BM samples but similar levels in PB samples. In children with stage 4 NB, TH expression levels significantly associated with the presence of BM and skeletal metastasis. Thus, RT-qPCR analysis of BM and PB samples showed potential clinical significance that should be evaluated in future multicentre prospective studies for infants with metastatic NB in comparison with conventional morphological evaluation and other prognostic factors evaluable in the primary tumors.

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