Inflammatory Bowel Disease: An Idiopathic Disease and its Treatment
Recent advancement in healthcare field made several disease and disorder curable by knowing their etiology and pathophysiology. But, there are many idiopathic diseases which are needed to be get more focused. Inflammatory bowel disease (IBD) is one of them. IBD, its exact cause is still unclear but there is involvement of genetic change or translocation or mutation which is provoked by unknown factor. IBD is classified into Crohn’s disease and ulcerative colitis. Both are differing in their pathophysiology as well as part of gastro intestinal tract where it affects. Crohn’s disease can affect any portion of the GI tract from the mouth to the anus and it mainly act through Th-1 cells. In Ulcerative colitis, inflammation begins in rectum and extends to the proximal colon and it is continuous without any ‘skip areas’.Th-2 cells play major role in pathophysiology of ulcerative colitis. Treatment of IBD requires proper diagnosis with endoscopy, pathology, radiology and careful attention on symptoms. Many pathways are involved in pathogenesis of IBD. Targeting or altering these pathways can be potential gear to treat disease and prevent its remission. This review underlines pathophysiology of IBD and targets which are available for its treatment.