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Inflammatory Breast Cancer Stem Cells: Contributors to Aggressiveness, Metastatic Spread and Dormancy | OMICS International | Abstract

Journal of Molecular Biomarkers & Diagnosis
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Review Article

Inflammatory Breast Cancer Stem Cells: Contributors to Aggressiveness, Metastatic Spread and Dormancy

Cynthia M. van Golen1, Kenneth L.van Golen2*

1Department of Biological Science, Delaware State University, USA

2Department of Biological Science, University of Delaware and The Helen F. Graham Cancer Center, USA

*Corresponding Author:
Kenneth L. van Golen
320 Wolf Hall, Department of Biological Science
The University of Delaware, Newark, DE 19716, USA
Tel: 302-831-2669
Fax: 302-831-2281
E-mail: [email protected]

Received date: May 21, 2012; Accepted date: June 20, 2012; Published date: June 25, 2012

Citation: van Golen CM, van Golen KL (2012) Inflammatory Breast Cancer Stem Cells: Contributors to Aggressiveness, Metastatic Spread and Dormancy. J Mol Biomarkers Diagn S8:002. doi:10.4172/2155-9929.S8-002

Copyright: © 2012 van Golen CM, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited


Cancer stem cell populations have been identified for several types of cancers and suggest a way for tumor cells to be resistant to therapies. Further, because of the longevity, endurance and replicative potential of cancer cells with stem-like properties, other malignant attributes such as recurrence after long periods of dormancy can also be explained. Inflammatory breast cancer (IBC) is a unique and aggressive form of breast cancer that has a clinical course unlike other forms of breast cancer. The main hallmark of IBC is prolific invasion of the dermal lymphatic vessels by tumor emboli leading to rapid metastasis of the disease. Despite an extremely aggressive treatment approach, the majority of women with IBC present with disease recurrence suggesting the presence of chemo resistant and/or dormant breast cancer cells. Current evidence suggests that IBC tumor emboli contain distinct populations of cells with stem cell-like properties. Thus, specific targeting of these stem cell-like cancer cells may be the key to effectively treating IBC.


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