alexa Inflammatory Fibroid Polyps of Large Bowel with PDGFRA Mutation
ISSN: 2157-7013

Journal of Cell Science & Therapy
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Case Report

Inflammatory Fibroid Polyps of Large Bowel with PDGFRA Mutation

Kanazu Ariyasu1, Riko Kitazawa1,2, Ryuma Haraguchi1, Yasuo Ueda1,2, Yukino Kawanami1, Yukiko Nishi1, Yuri Kameoka1, Yosuke Mizuno1,2 and Sohei Kitazawa1*

1Department of Molecular Pathology, Ehime University Graduate School of Medicine, Toon City, Ehime 791-0295, Japan

2Division of Diagnostic Pathology, Ehime University Hospital, Shitsukawa 454, Toon City, Ehime 791-0295, Japan

*Corresponding Author:
Sohei Kitazawa
Department of Molecular Pathology
Ehime University Graduate School of Medicine
Toon City, Ehime 791-0295, Japan
Tel: +0899605175
E-mail: [email protected]

Received date: November 07, 2015; Accepted date: February 15, 2016; Published date: February 18, 2016

Citation: Ariyasu K, Kitazawa R, Haraguchi R, Ueda Y, Kawanami Y, et al. (2016) Inflammatory Fibroid Polyps of Large Bowel with PDGFRA Mutation. J Cell Sci Ther 7:234. doi:10.4172/2157-7013.1000234

Copyright: © 2015 Ariyasu K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The presence of the platelet-derived growth factor receptor α (PDGFRA) gene mutation was examined in 2 cases of inflammatory fibroid polyp (IFP) in the large bowel. Immunohistochemical analysis of PDGFRA revealed one positive (Case 1) and one negative (Case 2) IFP. The lesions were then selectively microdissected from paraffinembedded specimens, based on typical histological features showing bland spindled cells arranged in whorls or in onionskin-like fashion around blood vessels or mucosal glands with eosinophilic cells. Case 1 carried a deletion with additional missense mutation causing framshifted-nonsense mutation in exon 14; Case 2 carried a missense mutation in exon 18. These findings confirmed that IFPs in the large bowel, albeit very rare, also share genetic alterations of PDGFRA similar to those in other gastrointestinal IFPs.


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