alexa Influence of a Regular, Standardized Meal on Lipid Profile of People with Diabetes
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Research Article

Influence of a Regular, Standardized Meal on Lipid Profile of People with Diabetes

Susana Garrido1*, Fernando Pichel1, Helena Neto1, Helena Ramos1, José Carlos Oliveira2 and Isabel Palma1

1Division of Metabolism, Endocrinology and Diabetes, Hospital de Santo António, Centro Hospitalar do Porto, Portugal

2Division of Clinical Chemistry, Hospital de Santo António, Centro Hospitalar do Porto, Portugal

Corresponding Author:
Susana Garrido
Serviço de Endocrinologia, Diabetes e Metabolismo
Hospital de Santo António, Centro Hospitalar do Porto
Largo Prof. Abel Salazar, 4099-001 - Porto, Portugal
Tel: 00351 22 207 7500
E-mail: [email protected]

Received Date: June 09, 2015 Accepted Date: September 14, 2015 Published Date: September 21, 2015

Citation: Garrido S, Pichel F, Neto H, Ramos H, Oliveira JC, et al. (2015) Influence of a Regular, Standardized Meal on Lipid Profile of People with Diabetes. J Mol Genet Med 9:182. doi:10.4172/1747-0862.1000182

Copyright: © 2015 Garrido S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Aims: The need to fast before lipid screening has been questioned in the past years. The aim of this study was to determine the influence of a light meal on the lipid profile in people with diabetes.
Methods: 115 participants with type 2 diabetes were recruited between April/2013-August/2014 from our Outpatient Diabetes Education Clinic. Clinical and analytical evaluation took place in 2 moments (8-hour fasting=t0; 2h after a light standardized meal=t1), with measurements of total cholesterol, LDL-cholesterol, HDL-cholesterol and triglycerides.
Results: Triglycerides concentration increased between the 2 moments (median difference t1-t0=0.07 mmol/L, p=0.002) but the total cholesterol, LDL-cholesterol, HDL-cholesterol and non HDL- cholesterol did not change significantly. Performing an analysis according to the LDL-cholesterol therapeutic goals proposed by Adult Treatment Panel III, we found an agreement between fasting and postprandial assessments of 91.1% for the goal of 2.6 mmol/L (102/112), and of 97.3% for the goal of 1.8 mmol/L (109/112). The same analysis was performed for the secondary goal, non HDL-cholesterol.
Conclusion: The data presented suggest that the nonfasting lipid profile can be an alternative to the fasting lipid profile in selected patients. Larger studies are needed to confirm these results and demonstrate an association of nonfasting lipemia and cardiovascular risk in individuals with diabetes.


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