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ISSN: 2329-9126

Journal of General Practice
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  • Research Article   
  • J Gen Pract 2017, Vol 5(6): 343
  • DOI: 10.4172/2329-9126.1000343

Influence of Diabetes and Hemodialysis against Nerve Conduction Studies

Yoshikane Kato1, Hiroshi Bando2*, Tomomi Fujikawa1, Miyuki Narutaki1, Masami Yamamoto1, Hideki Kakutani1, Yujiro Shirai1, Kazuyo Ishikura1, Kazuhiro Kusunoki1, Saeri Tanaka1, Takafumi Kawata1, Setsuko Kanazawa1, Sayuri Matsuzaki1, Masahiro Bando3 and Shinnichi Waka1
1Kanaiso Hospital, , Tokushima, Japan
2Tokushima University /Medical Research, , Japan
3Department of Nutrition and Metabolism, Institute of Biomedical Sciences, Tokushima University Graduate School, , Tokushima, Japan
*Corresponding Author : Hiroshi Bando, Tokushima University /Medical Research, Nakashowa 1-61, Tokushima 7700943, Japan, Tel: 819031872485, Fax: 81886031030, Email: [email protected]

Received Date: Dec 04, 2017 / Accepted Date: Dec 11, 2017 / Published Date: Dec 18, 2017


Background: Diabetic peripheral neuropathy (DPN) has been prevalent and discussed, and nerve conduction studies (NCS) has been continued. We have checked NCS using recently introduced useful DPN-Check device.
Subjects and Methods
: The subjects were 66 patients (pts) classified into 4 groups according to existence of diabetes mellitus (DM) and hemodialysis (HD); Group1: DM (+), HD (+) in 15 pts, group 2: DM (-), HD (+) in 15 pts, group 3: DM (+), HD (-) in 20 pts, group 4: 16 healthy controls. Methods included measurements of sural nerve conduction velocity (SNCV) and sural nerve action potential (SNAP) using HDN-1000.
Results: Average age in each group was 64.4 years to 72.6 years. SNCV value of 4 group in average was 37.1 m/sec, 46.3 m/sec, 49.3 m/sec, 53.2 m/sec, respectively, and value of group 1 was significantly lower than those of group 2,3,4 (p<0.01). Similarly, average SNAP was 4.1 μV, 8.7 μV, 8.0 μV, 21.6 μV, respectively, and group 1,2,3 were significantly lower than group 4 (p<0.01). There was significant correlation between SNCV and SNAP in all subjects (p<0.01). Significant correlations were shown between DM duration and SNCV, and DM duration and SNAP (p<0.01).
Discussion and Conclusion: SNCV and SNAP were measured successfully and easily by HDN-1000, indicating clinical availability. Obtained data suggested that 1) SNCV is not significantly decreased due to only uremic neuropathy, 2) SNCV is significantly decreased in patients with both HD and DM, 3) SNAP is significantly decreased in patents with DM for years and 4) SNAP would be remarkably decreased when HD is in addition to DM. These results would become the basal data of future NCS for DM and HD.

Keywords: Diabetic peripheral neuropathy; Nerve conduction studies; Sural nerve conduction elocity; Sural nerve action potential; Diabetes mellitus; Hemodialysis

Citation: Kato Y, Bando H, Fujikawa T, Narutaki M, Yamamoto M, et al. (2017) Influence of Diabetes and Hemodialysis against Nerve Conduction Studies. J Gen Pract (Los Angel) 5:343. Doi: 10.4172/2329-9126.1000343

Copyright: © 2017 Kato Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.