Influence of Diluents on Diclofenac Sodium Release from Gum Kondagogu Based Matrix Tablets.
The purpose of the study was to investigate the influence of formulation variables on the release profile of diclofenac sodium from gum kondagogu matrix tablets. Experimental design was applied to evaluate the influence of concentration of the gum and type of diluent with the final goal of drug release behavior optimization. Two independent variables considered were concentration of the gum (X1) and type of diluents (X2). The considered responses were the percentage drug released at three determined times (Q4, Q7, Q10), zero order rate constant and the time to release 50% of drug. Matrix tablets were prepared by wet granulation method. Physical properties and drug release studies were carried out for the prepared tablets. The physical properties indicated good handling properties of the prepared matrix tablets. Polynomial equations and response surface plots were generated for all dependent variables. The present study indicates that both the factors have a significant effect on drug release profile. The dissolution studies indicate the release behavior of all the formulations was super case II transport mechanism with zero order kinetics. The results demonstrate the reliability of the model in the preparation of matrix tablets of diclofenac sodium for sustained release using gum kondagogu with the selected diluents.