alexa Influence of Gut Microbiota on Inflammation and Pathoge
ISSN: 1745-7580

Immunome Research
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Research Article

Influence of Gut Microbiota on Inflammation and Pathogenesis of Sugar Rich Diet Induced Diabetes

Prasant Kumar Jena1,3, Bhumika Prajapati1, Pradyumna Kumar Mishra2 and Sriram Seshadri1*

1Institute of Science, Nirma University, Ahmedabad, Gujarat, India

2School of Biological Science, Dr. H.S Gour Central University, Sagar, MP, India

3Department of Medical Pathology and Laboratory Medicine, Davis Medical Centre, University of California, Sacramento, USA

Corresponding Author:
Sriram Seshadri
Institute of Science, Nirma University Sarkhej-Gandhinagar Highway
Chharodi, Ahmedabad-382481, Gujarat, India
Tel: +91 2717 241901-04 ext752
Fax: +91 2717 241916
E-mail: [email protected] or [email protected]

Received date: February 04, 2016; Accepted date: March 15, 2016; Published date: March 22, 2016

Citation: Jena PK, Prajapati B, Mishra PK, Seshadri S (2016) Influence of Gut Microbiota on Inflammation and Pathogenesis of Sugar Rich Diet Induced Diabetes. Immunome Res 12:109. doi:10.4172/1745-7580.10000109

Copyright: © 2016 Jena PK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Type 2 diabetes is characterized by peripheral insulin resistance. Besides immune and inflammatory mechanisms, other pathways involve interaction between gut microbiota and metabolic syndrome. The present study was designed to understand gut microbiota alteration following High Sugar Diet (HSD) and its effect on physiology and gastrointestinal immunology. Male wistar rats were fed with high fructose and HSD for 60 days. Composition of fecal microbiota by DGGE and proinflammatory cytokines in serum was investigated. Expressions of genes such as TLR2, TLR4 and NF-kB in various tissues were also studied. The bacteria coliforms and clostridium level were higher and Lactobacillus was lower in both sugar rich diet fed rats. Highly diverse and densely populated bands were observed in HSD group by DGGE fingerprint. The band profiles of sugar fed group have clustered together. Elevated mRNA expression of TLR2, TLR4, and NF-kB were observed in HSD groups. Increased inflammation was confirmed by blood and tissue biochemical assay and enhanced serum pro-inflammatory cytokines in HSD diet groups. Gut microbiota strongly influenced the metabolic profiling of individuals fed with high calorie intake. The diverse microbial population and increased coliforms and clostridium may affect host gene expression. Targeting TLRs and microbiota could be promising therapeutic approach


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