alexa Influence of Honey on Immune Status in Mice-Bearing Ehrlich Carcinoma | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Research Article

Influence of Honey on Immune Status in Mice-Bearing Ehrlich Carcinoma

Ahmed G Hegazi*, Eman H Abdel-Rahman, Fayrouz Abd-Allah and Amr M Abdou
Department of Zoonotic Diseases, National Research Center, Dokki, Giza, Egypt
Corresponding Author : Ahmed Hegazi
Department of Zoonotic Diseases
National Research Center, Egypt
Tel: +201001440063
Fax: +20237749222
E-mail: [email protected]
Received November 23, 2014, Accepted February 12, 2015, Published February 19, 2015
Citation: Hegazi AG, Abdel-Rahman EH, Abd-Allah F, Abdou AM (2015) Influence of Honey on Immune Status in Mice-Bearing Ehrlich Carcinoma. J Clin Cell Immunol 6:295. doi: 10.4172/2155-9899.1000295
Copyright: © 2015 Hegazi AG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Honey is currently the focus of many research projects due to its varied biological activities including antiinflammatory, antioxidant, antibacterial, antihypertensive and hypoglycemic effects. In the current study antitumor effect of coriander honey was investigated in mature mice bearing Ehrlich ascites carcinoma (EAC) with special reference to immune status. Coriander honey (500 mg/kg) caused decrease in tumor volume, packed cell volume and viable cell count, and caused increase in non-viable cell count and mean survival time thereby increasing life span of EAC bearing mice. The study of the effect of honey on immunological status in mice bearing Ehrlich carcinoma showed that the levels of immunoglobulin M, G and A were increased following the administration of coriander honey. It was also clear that coriander honey increased the phagocytic activity in mice bearing Ehrlich carcinoma. There was reduction in the stimulation indices of lymphocyte transformation of mice bearing Ehrlich carcinoma. Delayed hypersensitivity skin test revealed that the Ehrlich carcinoma reduced the reaction after 72 hours post inoculation with bovine serum albumin. The administration of honey caused the rise in skin thickness as shown in Ehrlich carcinoma and subsequently treated with coriander honey with a rise of 0.61 mm as compared with 0.52 mm in EAC control group. The skin thickness in coriander honey group was the highest among all groups with 0.90 mm thickness. Based on these results, it can be concluded that coriander honey exhibited antitumor effect by modulating cell mediated immune response and immunoglobulin levels, in EAC bearing mice.

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