alexa Influence of Lactobacillus and Bifidobacterium Combination on the Gut Microbiota, Clinical Course, and Local Gut Inflammation in Patients with Ulcerative Colitis: A Preliminary, Single-center, Open-label Study| Abstract

ISSN: 2329-8901

Journal of Probiotics & Health

  • Research Article   
  • J Prob Health 2017, Vol 5(1): 163
  • DOI: 10.4172/2329-8901.1000163

Influence of Lactobacillus and Bifidobacterium Combination on the Gut Microbiota, Clinical Course, and Local Gut Inflammation in Patients with Ulcerative Colitis: A Preliminary, Single-center, Open-label Study

Magdalena Pilarczyk-Zurek1, Malgorzata Zwolinska-Wcislo2, Tomasz Mach2, Krzysztof Okon3, Pawel Adamski4, Piotr B Heczko1, Aleksandra Mikolajczyk-Cichonska5, Grzegorz Stefanski5 and Magdalena Strus5*
1Department of Microbiology, Jagiellonian University Medical College, Cracow, Poland
2Department Of Gastroenterology, Hepatology and Infectious Diseases, Jagiellonian University Medical College, Cracow, Poland
3Department of Pathomorphology, Jagiellonian University Medical College, Cracow, Poland
4Polish Academy of Sciences, Institute of Nature Conservation, Cracow, Poland
5IBSS BIOMED SA., Sosnowa 8 Ave., Cracow, Poland
*Corresponding Author : Magdalena Strus, PhD, Department of Microbiology, Jagiellonian University Medical College, Czysta 18 Street, 31-121 Cracow, Poland, Tel: +48 12 633 25 67, Email: [email protected]

Received Date: Oct 12, 2016 / Accepted Date: Feb 10, 2017 / Published Date: Feb 17, 2017

Abstract

Background: Ulcerative colitis (UC) is one of the chronic, relapsing, inflammatory disorders of the gut and is characterized by inflammation limited in most cases to the colon. Since gut microbiota play a critical role in the development and perpetuation of intestinal inflammation, the addition of probiotics to this complex system may exert a positive influence on gut inflammatory reactions.
Methods: A single center, open-label, intention-to-treat study involving patients with moderate-to-severe UC was performed to check whether a probiotic mixture containing Lactobacillus plantarum, Lactobacillus rhamnosus, and Bifidobacterium longum given together with a standard treatment could decrease clinical and histopathology indexes for UC evaluation.
Results: The mixture given once a day for at least 2 months together with mesalazine and ciprofloxacin to patients in the acute phase of UC significantly reduced their Mayo Clinic Index values. Moreover, numbers of lactobacilli isolated from patients feces were significantly increased, while those of Gram-negative rods decreased. The mixture given together with mesalazine to patients with UC in remission also caused a decrease of their clinical scores, but a more prominent and significant decrease of the histopathological index values in biopsy samples was observed.
Conclusions: Supplementation of standard therapy with the probiotic mixture used in this study was efficacious in inducing and maintaining remission in UC, and this effect was related to modulation of dysbiosis in the gut microbiota.

Keywords: Ulcerative colitis; Probiotics

Citation: Pilarczyk-Zurek M, Zwolinska-Wcislo M, Mach T, Okon K, Adamski P, et al. (2017) Influence of Lactobacillus and Bifidobacterium Combination on the Gut Microbiota, Clinical Course, and Local Gut Inflammation in Patients with Ulcerative Colitis: A Preliminary, Single-center, Open-label Study. J Prob Health 5: 163. Doi: 10.4172/2329-8901.1000163

Copyright: © 2017 Pilarczyk-Zurek M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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