Influence of Long Term Administration of Nevirapine on Serum Liver Enzymes Profile in Albino Wistar Rats
Umoren EB*, Obembe AO, Odo MO and Osim EE
Department of Anatomy, College of Medical Sciences, University of Calabar, Calabar, Nigeria
- *Corresponding Author:
- Elizabeth B Umoren
Department of Anatomy
College of Medical Sciences University of Calabar
Calabar 540001, Nigeria
E-mail: [email protected]
Received date: November 12, 2014; Accepted date: August 12, 2015; Published date: August 18, 2015
Citation: Umoren EB, Obembe AO, Odo MO, Osim EE (2015) Influence of Long Term Administration of Nevirapine on Serum Liver Enzymes Profile in Albino Wistar Rats. J AIDS Clin Res 6:491. doi:10.4172/2155-6113.1000491
Copyright: © 2015 Umoren EB, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The effect of long term administration of nevirapine (NVP) on serum levels of some liver enzymes in albino Wistar rat was investigated. A group of rats treated with NVP (0.4 mg/kg body weight) for 2 weeks thereafter, two times daily in addition to normal rodent chow for 12 weeks were examined for serum levels of aspartate transaminase, alanine aminotransferase, alkanine phosphatase, gamma glutamyl transferase. The levels of aspartate transaminase (AST), alanine aminotransferase (ALT), alkanine phosphatase (ALP) and gamma glutamyl transferase (GGT) for the NVPtreated group were significantly (p < 0.001) higher as compared to their control(s), respectively. In conclusion, results of the study indicate that long term administration of NVP may be injurious to liver cell integrity, and this might impair liver function in the rat. If this result is applicable to humans, long term administration of NVP could hamper the integrity and function of the liver in individual users.