alexa Influence of Pathologic Complete Response to Induction Chemotherapy on Long-Term Survival of Patients Advanced Squamous Cell Carcinoma of the Oral Cavity Tongue | Abstract
ISSN: 2167-7700

Chemotherapy: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Influence of Pathologic Complete Response to Induction Chemotherapy on Long-Term Survival of Patients Advanced Squamous Cell Carcinoma of the Oral Cavity Tongue

Xin-rui Zhang1, Di Wu2,3, Zhi-min Liu2,3, Xue-kui Liu2,3*, Quan-Li2,3, Hao Li2,3, Zhu-ming Guo2,3 and Zong-yuan Zeng2,3

1Department of Otorhinolaryngology, Guangzhou Ear Nose Throat Neck Surgery Hospital, Guangzhou, P.R. China

2State Key Laboratory of Oncology in South China, P.R. China

3Department of Head and Neck Surgery, Cancer Center of Sun Yat-Sen University, Guangzhou, Guangdong, 510060, P.R. China

*Corresponding Author:
Xue-kui Liu, MD, PhD
Département of Head and Neck Surgery, Cancer Center
Sun Yat-Sen University, State Key Laboratory of Oncology in South China
Guangzhou, Guangdong, 510060, P.R. China
Tel: 020-87343300
E-mail: [email protected]

Received Date: March 13, 2014; Accepted Date: June 26, 2014; Published Date: June 30, 2014

Citation: Zhang XR, Wu D, Liu ZM, Liu XK, Li Q, et al. (2014) Influence of Pathologic Complete Response to Induction Chemotherapy on Long-Term Survival of Patients Advanced Squamous Cell Carcinoma of the Oral Cavity Tongue. Chemotherapy 3:133. doi:10.4172/2167-7700.1000133

Copyright: © 2014 Zhang XR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objective: To discuss long-term efficacy of preoperative induction chemotherapy (IC) plus surgery ± radiotherapy in patients with resectable stage III or IV squamous cell carcinoma of the oral cavity tongue (SCCOT). Methods: From June 1996 to December 2005, 73 patients with advanced SCCOT were treated with IC followed by surgery ± radiotherapy, at the Cancer Center of Sun Yat-sen University. The 5-year overall survival (OS), local control and reasons of treatment failure were analyzed retrospectively. Results: 73 patients aged from 22 to 77 years with untreated, clinical T1–4 N0-2M0 SCCOT underwent IC followed by surgery ± radiotherapy. After IC, 17 patients (23.3%) achieved clinical complete response; 44 patients (60.3%) clinical partial response; 12 patients (16.4%) no response or progression, and overall response rate was 89.0% (65/77). On final surgical pathology, 14 patients (19.2%) achieved histological complete response; 59 patients (80.8%) histological incomplete response. The 5-year OS was 59.8%, local control was 69.9% (51/73). No treatment-associated deaths occurred, and toxicity was modest. Conclusion: IC plus surgery ± radiotherapy was a treatment modality that was tolerated with encouraging survival outcome in advanced resectable SCCOT patients. Response rate with this regimen was limited, but the responders were associated with excellent prognosis.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2018-19
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

+1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2018 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
Leave Your Message 24x7