Influence of Pathologic Complete Response to Induction Chemotherapy on Long-Term Survival of Patients Advanced Squamous Cell Carcinoma of the Oral Cavity TongueXin-rui Zhang1, Di Wu2,3, Zhi-min Liu2,3, Xue-kui Liu2,3*, Quan-Li2,3, Hao Li2,3, Zhu-ming Guo2,3 and Zong-yuan Zeng2,3
- *Corresponding Author:
- Xue-kui Liu, MD, PhD
Département of Head and Neck Surgery, Cancer Center
Sun Yat-Sen University, State Key Laboratory of Oncology in South China
Guangzhou, Guangdong, 510060, P.R. China
E-mail: [email protected]
Received Date: March 13, 2014; Accepted Date: June 26, 2014; Published Date: June 30, 2014
Citation: Zhang XR, Wu D, Liu ZM, Liu XK, Li Q, et al. (2014) Influence of Pathologic Complete Response to Induction Chemotherapy on Long-Term Survival of Patients Advanced Squamous Cell Carcinoma of the Oral Cavity Tongue. Chemotherapy 3:133. doi:10.4172/2167-7700.1000133
Copyright: © 2014 Zhang XR, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To discuss long-term efficacy of preoperative induction chemotherapy (IC) plus surgery ± radiotherapy in patients with resectable stage III or IV squamous cell carcinoma of the oral cavity tongue (SCCOT). Methods: From June 1996 to December 2005, 73 patients with advanced SCCOT were treated with IC followed by surgery ± radiotherapy, at the Cancer Center of Sun Yat-sen University. The 5-year overall survival (OS), local control and reasons of treatment failure were analyzed retrospectively. Results: 73 patients aged from 22 to 77 years with untreated, clinical T1–4 N0-2M0 SCCOT underwent IC followed by surgery ± radiotherapy. After IC, 17 patients (23.3%) achieved clinical complete response; 44 patients (60.3%) clinical partial response; 12 patients (16.4%) no response or progression, and overall response rate was 89.0% (65/77). On final surgical pathology, 14 patients (19.2%) achieved histological complete response; 59 patients (80.8%) histological incomplete response. The 5-year OS was 59.8%, local control was 69.9% (51/73). No treatment-associated deaths occurred, and toxicity was modest. Conclusion: IC plus surgery ± radiotherapy was a treatment modality that was tolerated with encouraging survival outcome in advanced resectable SCCOT patients. Response rate with this regimen was limited, but the responders were associated with excellent prognosis.