Influence of Stromal Components on Lung Cancer Carcinogenesis
Laurie A. Shuman Moss* and William G. Stetler-Stevenson
Radiation Oncology Branch, National Cancer Institute, NIH, Bethesda, MD 20892-1500, USA
- *Corresponding Author:
- Laurie Shuman Moss, Ph.D
Radiation Oncology Branch, National Cancer Institute
NIH, Bldg 10, Room 2A33, 10 Center Dr
MSC 1500, Bethesda, MD 20892-1500, USA
E-mail: [email protected]
Received Date: April 09, 2013; Accepted Date: June 15, 2013; Published Date: June 25, 2013
Citation: Moss LAS, Stevenson WGS (2013) Influence of Stromal Components on Lung Cancer Carcinogenesis. J Carcinogene Mutagene S13:008. doi: 10.4172/2157-2518.S13-008
Copyright: © 2013 Moss LAS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The association between tumor growth and angiogenesis was first observed over 100 years ago. Since then, research has shown the dependence of tumor growth on angiogenesis and the ability of cancer cells to alter the stromal microenvironment. Technological advancements have enabled researchers to identify cell types within a tumor, identify chemokines, cytokines, and growth factors secreted by tumor cells, show the interaction between tumor cells and stroma, and investigate the function of distinct genes using knockout and transgenic mouse technology. This review provides an overview of tumor growth, emphasizing research using in vivo mouse models on vascular endothelial growth factor (VEGF), fibrinogen, fibronectin, plasminogen, and MMPs in primary tumor growth and metastasis of lung cancer in particular.