Informed Carbohydrate Active Enzyme Discovery within the Human Distal Gut MicrobiomeAbbott DW*
Lethbridge Research Centre, Agriculture and Agri-Food Canada, 5403-1st Ave Lethbridge, AB, Canada, T1J4B1
- *Corresponding Author:
- Abbott DW
Lethbridge Research Centre, Agriculture and Agri-Food Canada
5403-1st Ave Lethbridge, AB, Canada, T1J4B1
E-mail: [email protected]
Received Date: July 14, 2014; Accepted Date: August 13, 2014; Published Date: August 16, 2014
Citation: Abbott DW (2014) Informed Carbohydrate Active Enzyme Discovery within the Human Distal Gut Microbiome. J Glycomics Lipidomics 4:119. doi: 10.4172/2153-0637.1000119
Copyright: © 2014 Abbott DW. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Next-generation sequencing of bacterial communities such as the human distal gut microbiome has generated a vast metagenomic sequence space. A common feature emerging from these analyses is that the genomes of intestinal bacteria are enriched with genes dedicated to the metabolism of indigestible dietary polysaccharides. Although cultureindependent techniques are unparalleled in their ability to probe and catalog carbohydrate active enzyme gene diversity within complex communities, downstream functional genomic approaches are still required to elucidate the mechanisms by which these enzymes and pathways function. Harnessing the potential of biocatalytic repositories, such as the human distal gut microbiome, will continue to facilitate the informed discovery of potent enzymes and help drive innovation towards the sustainable conversion of plant cell wall biomass.