alexa Inhibition of TNFa in Patients with Concomitant HCV Infection; Molecular Insights and Safety | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Inhibition of TNFa in Patients with Concomitant HCV Infection; Molecular Insights and Safety

Athina Pyrpasopoulou*, Stella Douma, Eleni Gavriilaki, Panagiota Anyfanti and Spyros Aslanidis
2nd Propedeutic Department of Internal Medicine, Hippokration GH, Thessaloniki, Greece
Corresponding Author : Dr. Athina Pyrpasopoulou, PhD
2nd Propedeutic Department of Internal Medicine
Konstantinoupoleos 49, 54643 Thessaloniki, Greece
Tel: +302310892072
Fax: +302310992834
E-mail: [email protected]
Received October 03, 2012; Accepted November 07, 2012; Published November 13, 2012
Citation: Pyrpasopoulou A, Douma S, Gavriilaki E, Anyfanti P, Aslanidis S (2012) Inhibition of TNFa in Patients with Concomitant HCV Infection; Molecular Insights and Safety. J Clin Cell Immunol S1:004. doi:10.4172/2155-9899.S1-004
Copyright: © 2011 Pyrpasopoulou A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Chronic viral infections, such as chronic hepatitis C, are major causes of disease worldwide. They represent model systems for the study both of sophisticated ways to elute host defense mechanisms, and of mechanisms to sustain inflammation, potentially leading to autoimmune manifestations as a side effect. Cytokines are central inducers and regulators of both immune-mediated virus clearance and of immunopathology. This review describes the potential implications of TNFa in the development and clinical progression of chronic hepatitis C infection. The frequency of chronic hepatitis C, its usually indolent course, and the current application of these biological agents for the management of continuously expanding therapeutic indices, renders the study of the molecular effects and safety of TNFa antagonists in chronic HCV carriers of particular clinical significance.

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