alexa Inhibition of Tumors in Mice Models by a Synthetic Ceramide-analog AD2725
ISSN: 2167-0501

Biochemistry & Pharmacology: Open Access
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Research Article

Inhibition of Tumors in Mice Models by a Synthetic Ceramide-analog AD2725

Qin JD1,2*, Weiss L3, Zeira M3, Yekhtin Z3, Slavin S3,4, Gatt S2 and Dagan A2,5

1Department of Pediatrics, The University of Chicago, Chicago, USA

2Department of Biochemistry, Hebrew University School of Medicine, Jerusalem, Israel

3Department of Bone-Marrow Transplantation, Hadassah–Hebrew University of Medical Center, Jerusalem, Israel

4The International Center for Cell Therapy & Cancer Immunotherapy, Tel Aviv, Israel

4Department of Biochemistry and Molecular Biology, Institute for Medical Research Israel-Canada, Hebrew-University-Hadassah School of Medicine, Jerusalem, Israel

*Corresponding Author:
Jingdong Qin, Ph.D.
Department of Pediatrics
The University of Chicago
5841 S Maryland Ave
Wyler MC4068
Chicago, IL, USA
Tel: 7737026441
Fax: 7737029234
E-mail: [email protected]

Received date: April 27, 2016; Accepted date: June 23, 2016; Published date: June 29, 2016

Citation: Qin JD, Weiss L, Zeira M, Yekhtin Z, Slavin S, et al. (2016) Inhibition of Tumors in Mice Models by a Synthetic Ceramide-analog AD2725. Biochem Pharmacol (Los Angel) 5:212. doi:10.4172/2167-0501.1000212

Copyright: © 2016 Qin JD. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

A synthetic analog of ceramide (AD2725) elevated ceramide levels in MDA-MB-435 breast cancer cells inducing apoptosis and resulted in cell death. In animal studies, using a model of xenograft breast cancer cancer cells in nude mice, treatment with AD2725 resulted in a significant reduction of the tumor volume and weight, and a significantly prolonged survival of the treated mice. The analog also significantly elevated INF gamma and IL-12 cytokine levels and reduced the level of IL-10 in the plasma. These data indicate that use of suitable synthetic analogs that most probably elevate the ceramide levels may have beneficial anti-cancer therapeutic effects.

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