Inhibition of Tumors in Mice Models by a Synthetic Ceramide-analog AD2725
- *Corresponding Author:
- Jingdong Qin, Ph.D.
Department of Pediatrics
The University of Chicago
5841 S Maryland Ave
Chicago, IL, USA
E-mail: [email protected]
Received date: April 27, 2016; Accepted date: June 23, 2016; Published date: June 29, 2016
Citation: Qin JD, Weiss L, Zeira M, Yekhtin Z, Slavin S, et al. (2016) Inhibition of Tumors in Mice Models by a Synthetic Ceramide-analog AD2725. Biochem Pharmacol (Los Angel) 5:212. doi:10.4172/2167-0501.1000212
Copyright: © 2016 Qin JD. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
A synthetic analog of ceramide (AD2725) elevated ceramide levels in MDA-MB-435 breast cancer cells inducing apoptosis and resulted in cell death. In animal studies, using a model of xenograft breast cancer cancer cells in nude mice, treatment with AD2725 resulted in a significant reduction of the tumor volume and weight, and a significantly prolonged survival of the treated mice. The analog also significantly elevated INF gamma and IL-12 cytokine levels and reduced the level of IL-10 in the plasma. These data indicate that use of suitable synthetic analogs that most probably elevate the ceramide levels may have beneficial anti-cancer therapeutic effects.