alexa Inhibitory Effect of Isoflavones from Processed Soybeans on Human DNA Topoisomerase II Activity | OMICS International
ISSN: 2329-9029

Journal of Plant Biochemistry & Physiology
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Short Communication

Inhibitory Effect of Isoflavones from Processed Soybeans on Human DNA Topoisomerase II Activity

Isoko Kuriyama1 , Hiromi Yoshida1 , Yoshiyuki Mizushina1,2* and Yoshihiro Takahashi3
1Laboratory of Food & Nutritional Sciences, Faculty of Nutrition, Kobe Gakuin University, Nishi-ku, Kobe, Hyogo 651-2180, Japan
2 Cooperative Research Center of Life Sciences, Kobe Gakuin University, Chuo-ku, Kobe, Hyogo 650-8586, Japan
3 Laboratory of Research and Development, Oguraya Yanagimoto Co., Ltd., Higashi-Nada-ku, Kobe, Hyogo 658-0044, Japan
Corresponding Author : Yoshiyuki Mizushina
Cooperative Research Center of Life Sciences
Kobe Gakuin University, Chuo-ku
Kobe, Hyogo 650-8586, Japan
Tel: +81-78-974-1551
Fax: +81-78-974-5689
E-mail: [email protected]
Received March 28, 2013; Accepted May 05, 2013; Published May 12, 2013
Citation: Kuriyama I, Yoshida H, Mizushina Y, Takahashi Y (2013) Inhibitory Effect of Isoflavones from Processed Soybeans on Human DNA Topoisomerase II Activity. J Plant Biochem Physiol 1:106. doi:10.4172/2329-9029.1000106
Copyright: © 2013 Kuriyama I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

In this study, we found that the amount of isoflavones in (1) steaming germinated soybean was higher than that



of (2) soybean boiled in water and (3) steamed soybean. Moreover, genistein, a major soy isoflavone, selectively



inhibited the activity of human topo II. Therefore, steaming germinated soybean, which has high amount of genistein,



might be a cancer preventive food through the inhibition of topo II activity.

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