alexa Initial Study on 3D Porous Silk Fibroin Scaffold: Preparation and Morphology
ISSN:2090-5025

Bioceramics Development and Applications
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Research Article

Initial Study on 3D Porous Silk Fibroin Scaffold: Preparation and Morphology

Yong Zhao1* R. Z Legeros2 and Jing Chen1

1The Department of Dental Materials, West China College of Stomatology, Sichuan University, Chengdu 610041, China

2Calcium Phosphate Research Lab, Department of Biomaterials & Biomimetics, New York University College of Dentistry, NY 10010, USA

Corresponding Author:
Yong Zhao
E-mail:
zhaodt [email protected]

Received date: March 14, 2016; Accepted date: April 19, 2016

Abstract

Objective. The aim of the present study is to prepare a 3D porous silk fibroin scaffold with a hierachical structure that can meet the demands for bone tissue engineering. Materials and Methods. 3D fibroin scaffold was prepared by the methods of partial dissolution in acid solution and freeze drying fibroin solution. Results. The nets were composed of a mesh of randomly oriented fibers that ranged between 10 ?m and 30 ?m in diameter. Branchpoints and three dimensional open spaces were distributed throughout the structure with an average pore size of about 177.9 ± 40.0 ?m. Conclusion. With the methods of non-woven silk fibroin net preparation and frozen-dried technics, it is possible to prepare a 3D porous silk fibroin scaffold with hierachical fine structure.

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