alexa Initiation of DNA Replication in the Human Genome
ISSN: 2161-1041

Hereditary Genetics: Current Research
Open Access

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Review Article

Initiation of DNA Replication in the Human Genome

Manuel S. Valenzuela*

Department of Biochemistry and Cancer Biology, School of Medicine, Meharry Medical College, 1005 D.B. Todd Jr. Boulevard, Nashville, TN 37208 , USA

*Corresponding Author:
Manuel S. Valenzuela
Department of Biochemistry and Cancer Biology
School of Medicine Meharry Medical College
1005 D.B. Todd Jr. Boulevard Nashville, TN 37208, USA
Tel: 615-327-6253
Fax: 615-327-6442
E-mail: [email protected]

Received Date: January 02, 2012; Accepted Date: February 03, 2012; Published Date: February 08, 2012

Citation: Valenzuela MS (2012) Initiation of DNA Replication in the Human Genome. Hereditary Genetics S1:003 doi: 10.4172/2161-1041.S1-003

Copyright: © 2012 Valenzuela MS. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Replication of the human genome relies on the presence of thousands of origins distributed along each of the
chromosomes. The activation of these origins occurs in a highly regulated manner to ensure that chromosomes are
faithfully duplicated only once during each cell cycle. Failure in this regulation can lead to abnormal cell proliferation, or/
and genomic instability, the hallmarks of cancer cells. The mechanisms determining how, when, and where origins are
activated remains still a mystery. However recent technological advances have facilitated the study of DNA replication
in a genome-wide scale, and have provided a wealth of information on several features of this process. Here we
present an overview of the current progress on our understanding of the initiation step of DNA replication in human
cells, and its relationship to abnormal cell proliferation.

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