Innate Immunity in the Lower Female Mucosal Tract
- *Corresponding Author:
- Dr. Miranda A. Farage PhD
Feminine Clinical Sciences
The Procter & Gamble Company, Winton Hill Business Centre
6110 Centre Hill Rd, P.O. Box 136,Cincinnati, OH 45224, USA
Tel: (513) 634-5594
Fax: (866) 622-0465
Received date: July 20, 2011; Accepted date: September 05, 2011; Published date: September 08, 2011
Citation: Farage MA, Miller KW, Gerberick GF, Saito FH, Ledger WJ, et al. (2011) Innate Immunity in the Lower Female Mucosal Tract. J Steroids Hormon Sci 2:106. doi:10.4172/2157-7536.1000106
Copyright: © 2011 Farage MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The moist, nonkeratinized surfaces of mucosal tissues face a significant challenge with regard to protection of internal tissues from pathogenic invaders, a situation augmented by the fact that these sites are colonized by commensal microorganisms. The mucosa of the human reproductive tract is unique in that it must also balance the need for immunologic vigilance against pathogenic microorganisms and neoplastic cells with its critical role in reproduction, successfully creating an immune environment that tolerates allogeneic spermatozoa as well as the semi-allogeneic developing fetus. This article reviews the components of innate immunity that are functional in the cervicovaginal environment.