alexa Innate Immunity in the Lower Female Mucosal Tract
ISSN: 2157-7536

Journal of Steroids & Hormonal Science
Open Access

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Review Article

Innate Immunity in the Lower Female Mucosal Tract

Miranda A. Farage1*, Kenneth W. Miller1, G. Frank Gerberick1, Felipe H. Saito2, William J. Ledger3 and Steven S. Witkin3

1The Procter and Gamble Company, Cincinnati, OH, USA

2Department of Gynecology and Obstetrics, Botucatu Medical School, Sao Paulo State University/UNESP, Botucatu, Brazil

3Department of Obstetrics and Gynecology, Weill Medical College of Cornell University, New York, USA

*Corresponding Author:
Dr. Miranda A. Farage PhD
Feminine Clinical Sciences
The Procter & Gamble Company, Winton Hill Business Centre
6110 Centre Hill Rd, P.O. Box 136,Cincinnati, OH 45224, USA
Tel: (513) 634-5594
Fax: (866) 622-0465

Received date: July 20, 2011; Accepted date: September 05, 2011; Published date: September 08, 2011

Citation: Farage MA, Miller KW, Gerberick GF, Saito FH, Ledger WJ, et al. (2011) Innate Immunity in the Lower Female Mucosal Tract. J Steroids Hormon Sci 2:106. doi:10.4172/2157-7536.1000106

Copyright: © 2011 Farage MA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The moist, nonkeratinized surfaces of mucosal tissues face a significant challenge with regard to protection of internal tissues from pathogenic invaders, a situation augmented by the fact that these sites are colonized by commensal microorganisms. The mucosa of the human reproductive tract is unique in that it must also balance the need for immunologic vigilance against pathogenic microorganisms and neoplastic cells with its critical role in reproduction, successfully creating an immune environment that tolerates allogeneic spermatozoa as well as the semi-allogeneic developing fetus. This article reviews the components of innate immunity that are functional in the cervicovaginal environment.


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