alexa Innovations of Photodynamic Therapy for Brain Tumors: Potential of Multifunctional Nanoparticles
ISSN: 2157-2518

Journal of Carcinogenesis & Mutagenesis
Open Access

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Review Article

Innovations of Photodynamic Therapy for Brain Tumors: Potential of Multifunctional Nanoparticles

Denise Bechet1, Céline Frochot2,4, Regis Vanderesse3,4 and Muriel Barberi-Heyob1,4*

1CRAN, Centre de Recherche en Automatique de Nancy, UMR 7039 CNRS, Lorraine-University, Centre Alexis Vautrin, Brabois, Vandoeuvre-lès-Nancy, France

2LRGP, Laboratoire Réactions et Génie des Procédés, UPR 3349 CNRS, Lorraine-University, Nancy, France

3LCMP, Laboratoire de Chimie-Physique Macromoléculaire, UMR 7568 CNRS, Lorraine-University, Nancy

4GDR 3049 “Médicaments Photoactivables – Photochimiothérapie (PHOTOMED)”, France

*Corresponding Author:
Barberi-Heyob M
CRAN, Research Center for Automatic Control of Nancy
UMR 7039 CNRS, Lorraine-University
Centre Alexis Vautrin
Brabois, Vandoeuvre-lès-Nancy, France
Tel: 33-3-83-59-83-76
Fax: 33-3-83-59-83-78

Received date: December 21, 2011; Accepted date:January 10, 2012; Published date:January 13, 2012

Citation: Bechet D, Frochot C, Vanderesse R, Barberi-Heyob M (2012) Innovations of Photodynamic Therapy for Brain Tumors: Potential of Multifunctional Nanoparticles. J Carcinogene Mutagene S8:001. doi: 10.4172/2157-2518.S8-001

Copyright: © 2012 Bechet D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



The poor outcome of primary malignant brain tumors is predominantly due to local invasion and recurrence. Multifunctional nanoparticles harbouring various functions including targeting, imaging and treatment have been intensively studied aiming to overcome limitations associated with conventional cancer diagnosis and therapy. Multifunctionality can be engineered into a single nanoplatform to provide tumour-specific detection, treatment, and follow-up. This review summarizes different targeting strategies for construction of multifunctional nanoparticles including magnetic nanoparticles-based theranostic systems, and the various surface engineering strategies of nanoparticles for in vivo applications. Using nanoparticles as carriers of photoactivable compounds is a very promising approach as they can satisfy all the requirements for an ideal photodynamic therapy agent. Nanoparticles represent emerging photosensitizer carriers that show great promise for PDT.

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