alexa Insects Offer a Useful Invertebrate Model to Screen Antimicrobial Libraries In Vivo
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Letter to Editor

Insects Offer a Useful Invertebrate Model to Screen Antimicrobial Libraries In Vivo

Ruqaiyyah Siddiqui and Naveed Ahmed Khan*

Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan

*Corresponding Author:
Naveed Ahmed Khan
Department of Biological and Biomedical Sciences
Aga Khan University, Stadium Road
Karachi, Pakistan
Tel: 92-(0)21-3486-4540
Fax: 92-(0)21-3493-4294
E-mail: [email protected]

Received Date: July 17, 2014; Accepted Date: August 20, 2014; Published Date: August 25, 2014

Citation: Siddiqui R, Khan NA (2014) Insects Offer a Useful Invertebrate Model to Screen Antimicrobial Libraries In Vivo. J Cell Sci Ther 5:171. doi: 10.4172/2157-7013.1000171

Copyright: © 2014 Siddiqui R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

This report describes an invertebrate, Locusta migratoria as an in vivo model to screen potential antimicrobial compounds (chemical libraries) to combat infectious diseases. Locusts were infected with 2 x 106 c.f.u. of Pseudomonas aeruginosa or Methicillin-resistant Staphylococcus aureus (MRSA) and mortality recorded at 67% and 52%, respectively within 24 h. To validate the suitability of locust model to test the efficacy of potential antimicrobials, locusts were injected with P. aeruginosa or MRSA, followed by injection of the gentamicin. Our results show that the group treated with gentamicin resisted the bacterial infection, while the untreated group presented high mortality. It is believed that the simple locust model described in the present study has the scope in exploring the efficacy of novel drugs (testing large chemical libraries) in microbial diseases, allowing inexpensive, rapid, and even high-throughput experimentation that has no legislative restrictions.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords