alexa Insects Offer a Useful Invertebrate Model to Screen Antimicrobial Libraries In Vivo | OMICS International | Abstract
ISSN: 2157-7013

Journal of Cell Science & Therapy
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Letter to Editor

Insects Offer a Useful Invertebrate Model to Screen Antimicrobial Libraries In Vivo

Ruqaiyyah Siddiqui and Naveed Ahmed Khan*

Department of Biological and Biomedical Sciences, Aga Khan University, Karachi, Pakistan

*Corresponding Author:
Naveed Ahmed Khan
Department of Biological and Biomedical Sciences
Aga Khan University, Stadium Road
Karachi, Pakistan
Tel: 92-(0)21-3486-4540
Fax: 92-(0)21-3493-4294
E-mail: [email protected]

Received Date: July 17, 2014; Accepted Date: August 20, 2014; Published Date: August 25, 2014

Citation: Siddiqui R, Khan NA (2014) Insects Offer a Useful Invertebrate Model to Screen Antimicrobial Libraries In Vivo. J Cell Sci Ther 5:171. doi: 10.4172/2157-7013.1000171

Copyright: © 2014 Siddiqui R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

This report describes an invertebrate, Locusta migratoria as an in vivo model to screen potential antimicrobial compounds (chemical libraries) to combat infectious diseases. Locusts were infected with 2 x 106 c.f.u. of Pseudomonas aeruginosa or Methicillin-resistant Staphylococcus aureus (MRSA) and mortality recorded at 67% and 52%, respectively within 24 h. To validate the suitability of locust model to test the efficacy of potential antimicrobials, locusts were injected with P. aeruginosa or MRSA, followed by injection of the gentamicin. Our results show that the group treated with gentamicin resisted the bacterial infection, while the untreated group presented high mortality. It is believed that the simple locust model described in the present study has the scope in exploring the efficacy of novel drugs (testing large chemical libraries) in microbial diseases, allowing inexpensive, rapid, and even high-throughput experimentation that has no legislative restrictions.

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