Insights into the Molecular Antiviral Mechanism of Pokeweed Protein from Phytolacca americana
Valentina R Aitbakieva and Artem V Domashevskiy*
Department of Sciences, John Jay College of Criminal Justice, City University of New York, NY 10019, USA
- *Corresponding Author:
- Artem V Domashevskiy
Department of Sciences
John Jay College of Criminal Justice
City University of New York
524 West 59th Street, New York
NY 10019, USA
Tel: 91 6465574640
Fax: 91 2126213739
Received Date: June 02, 2016; Accepted Date: June 14, 2016; Published Date: June 17, 2016
Citation: Aitbakieva VR, Domashevskiy AV (2016) Insights into the Molecular Antiviral Mechanism of Pokeweed Protein from Phytolacca americana. Biochem Pharmacol (Los Angel) 5:210. doi: 10.4172/2167-0501.1000210
Copyright: © 2016 Domashevskiy AV. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited..
Agriculture is an indispensable part of every person’s life, ensuring that nutritious and inexpensive food is readily available. As any other organisms, plants are subject to numerous parasitic infections. Biological evolution has allowed plants to produce a variety of toxic compounds to deal with their pathogens. American pokeweed plant (Phytolacca americana) manufactures pokeweed antiviral protein, a ribosome inactivating protein that disrupts protein synthesis and lowers infectivity of many plant and animal viruses. The intricate mechanism of PAP antiviral activity entails a delicate coordination and interplay of several factors, allowing the plant to battle its invaders. Here, we examine the molecular mechanism of this plant peptide, and describe a molecular model of pokeweed’s antiviral activity.