alexa Insilco Modeling of Commonly Occurring Genetic Polymorphism of Human CYP3A4 on the Binding Affinity to UR-144
ISSN: 0974-8369

Biology and Medicine
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Research Article

Insilco Modeling of Commonly Occurring Genetic Polymorphism of Human CYP3A4 on the Binding Affinity to UR-144

Amene Tesfaye1* and Libargachewu Demlie2

1Department of Pharmacy, Pharmacology Unit, College of Health Sciences, Jimma University, P. O. Box: 378, Jimma, Ethiopia

2Department of Chemistry, College of Natural Science, Mekele University, P. O.Box:231, Mekele, Ethiopia

*Corresponding Author:
Amene Tesfaye
Department of Pharmacy, Pharmacology Unit
College of Health Sciences
Jimma University, P. O. Box: 378
Jimma, Ethiopia
Tel: +251 47 111 1458
E-mail: [email protected]

Received Date: December 01, 2016; Accepted Date: February 06, 2016; Published Date: February 13, 2017

Citation: Tesfaye A, Demlie L (2017) Insilco Modeling of Commonly Occurring Genetic Polymorphism of Human CYP3A4 on the Binding Affinity to UR-144. Biol Med (Aligarh) 9: 380. doi:10.4172/0974-8369.1000380

Copyright: © 2017 Tesfaye A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution and reproduction in any medium, provided the original author and source are credited.

 

Abstract

CYP3A4 accounts for about 30% in the human hepatic metabolism of xenobiotics. The defending mechanism of drug or xenobiotic metabolizing enzymes, particularly CYP superfamily has been found to be altered by both genetic polymorphisms and the environmental factors. The aim of this study was to examine UR-144 binding to CYP3A4 wild type and six different natural variants (I118V, R130Q, R162Q, D174H, T185S and L373F). A rigid ligand was docked by AutoDock Vina to flexible amino acid residues selected from the residues forming the binding pocket. The analysis of the docking results showed there is no difference in the binding affinities between the wild type and the natural variants. However, comparing the absolute binding affinity, the wild type (-12.8kcal/mol) has shown, among all, the lowest binding energy. Thus, this study depicts that the SNPs of CYP3A4 do not have any effects on the binding affinity of UR-144 to the active site.

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