alexa Intake of the First-Generation Anti-Histamines in Early Childhood May Have an Adverse Effect on Cognitive Function. Population Based Pharmacoepidemiologic Study in Non-Asthamtic Children
ISSN: 2167-1052

Advances in Pharmacoepidemiology and Drug Safety
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Research Article

Intake of the First-Generation Anti-Histamines in Early Childhood May Have an Adverse Effect on Cognitive Function. Population Based Pharmacoepidemiologic Study in Non-Asthamtic Children

Wieslaw A Jedrychowski1*, Elżbieta Flak1, Elzbieta Mroz1, Maria Butscher2 and Agata Sowa1
1Chair of Epidemiology and Preventive Medicine, Jagiellonian University Medical College in Krakow, Poland
2Polish-American Institute of Pediatrics, Jagiellonian University Medical College in Krakow, Poland
*Corresponding Author : Wieslaw A Jedrychowski
Department of Epidemiology and Preventive Medicine
Jagiellonian University Medical College
7, Kopernika Street, Krakow, Poland
Tel: +48-12-423-1003
Fax: +48-12-422-8795
E-mail: [email protected]
Received April 25, 2013; Accepted July 27, 2013; Published July 29, 2013
Citation: Jedrychowski WA, Flak E, Mroz E, Butscher M, Sowa A (2013) Intake of the First-Generation Anti-Histamines in Early Childhood May Have an Adverse Effect on Cognitive Function. Population Based Pharmacoepidemiologic Study in Non-Asthamtic Children. Adv Pharmacoepidemiol Drug Saf 2:138. doi:10.4172/2167-1052.1000138
Copyright: © 2013 Jedrychowski WA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

As the allergic diseases increase steadily worldwide, the main goal of the study was to assess the association between the early intake of the first-generation sedative antihistamines in young non-asthmatic children and their cognitive function at the age of 7. The size of the exposure effect was measured by the Wechsler intelligence Scale for Children (WISC-R) and adjusted in multivariable models for major confounders known to be important for children cognitive development. The study included 212 children who were non-asthmatic and completed the monitoring of antihistamines intake over 3 years preceding the WISC-R intelligence testing. While the first-generation drugs were used by 36.7% children and the newer generation by 39.6%, both categories of drugs were taken by 17.8% children. The analysis showed the deficit of 12 points on the verbal WISC-R IQ scale only in children who used the first- generation antihistamines for a longer time (beta coeff.=-11.7, 95% CI: -19.6, -3.7) compared to non-users. Out of the covariates included in the multivariable regression models, maternal education (beta coeff.=0.92, 95% CI: 0.37, 1.46) and breastfeeding at least for 6 months (beta coeff.=3.29; 95% CI: 0.34, 6.23) showed a significant positive impact on the verbal IQ. Intake of the newer generation antihistamines were associated neither with verbal nor performance IQ scores. Concluding, the results suggest that the “sedative antihistamines” have a negative impact on the verbal but not performance IQs of young children if drugs were used over a longer period. The weaker verbal communication ability of young children may hinder the cognitive development of children and be associated with relatively poor school academic achievements

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