alexa Integration of Gene Coexpression Network, GO Enrichment Analysis for Identification Gene Expression Signature of Invasive Bladder Carcinoma | OMICS International
ISSN: 2329-8936

Transcriptomics: Open Access
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Integration of Gene Coexpression Network, GO Enrichment Analysis for Identification Gene Expression Signature of Invasive Bladder Carcinoma

Hanaa Hibishy Gaballah*
Department of Medical Biochemistry and Molecular Biology, Faculty of Medicine, Tanta University, Egypt.
Visiting researcher at Bioinformatic Centre, Chemical Research Lab, Kyoto University, Japan.
Corresponding Author : Hanaa Hibishy Gaballah
Visiting Researcher at Bioinformatic Centre
Chemical Research Lab, Kyoto University, Japan
Tel:+201110077010
E-mail: [email protected]
Received November 06, 2015; Accepted January 07, 2016; Published January 11, 2016
Citation: Gaballah HH (2016) Integration of Gene Coexpression Network, GO Enrichment Analysis for Identification Gene Expression Signature of Invasive Bladder Carcinoma. Transcriptomics 4:126. doi:10.4172/2329-8936.1000126
Copyright: © 2016 Gaballah HH. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Related article at Pubmed, Scholar Google
 

Abstract

Bladder carcinoma is the most common malignancy of the urinary tract. Identification of genetic biomarkers for tumor invasiveness will help in earlier diagnosis and proper treatment. The present study aimed to integrate coexpression network and GO enrichment analysis for identification of prognostic markers and key genes that contribute to bladder cancer initiation and progression using a DNA microarray dataset (GSE 37317), invasive and noninvasive bladder cancer genes were compared by applying weighted gene co-expression network, gene ontology and pathway analysis. This study identified candidate genes (PURA, SRPK2, TRAK1, BRD2, and UPF3) that might have significant role in progression and invasiveness of bladder carcinoma. These markers might aid in early diagnosis of muscle invasiveness of bladder cancer. In conclusion; these finding may provide better understanding of the molecular mechanism of bladder cancer progression and invasiveness.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version