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Journal of Computer Science & Systems Biology
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Research Article

Integration of Pro-Apoptosis and Pro-Survival Signalling Pathways: A Useful Approach to In silico Biomedical Research

Maura Cárdenas-García1 and Pedro Pablo González-Pérez2*

1Benemérita Universidad Autónoma de Puebla, Facultad de Medicina. Edificio de Biomedicina 11 Sur 2702, Puebla, 72410, México

2Universidad Autónoma Metropolitana, Departamento de Matemáticas Aplicadas y Sistemas, Avenida Constituyentes 647, D.F., 11810, México

*Corresponding Author:
Pedro Pablo González-Pérez
Universidad Autónoma Metropolitana
Departamento de Matemáticas Aplicadas y Sistemas
Avenida Constituyentes 647, D.F., 11810, México
Tel: +525526363680
E-mail:[email protected]

Received date: August 14, 2013; Accepted date: August 26, 2013; Published date: August 31, 2013

Citation: Cárdenas-García M, González-Pérez PP (2013) Integration of Pro-Apoptosis and Pro-Survival Signalling Pathways: A Useful Approach to In silico Biomedical Research J Comput Sci Syst Biol 6:206-214. doi:10.4172/jcsb.1000118

Copyright: © 2013 Cárdenas-García M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License,which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Cells communication is absolutely essential for multi-cellular organisms, but what if a cell fails to send out a signal at the proper time? Or what if a signal doesn’t reach its target? What if a target cell does not respond to a signal or a cell responds even though it has not received a signal? These cellular phenomena can lead to serious metabolic alterations, but of course there are molecules that block these errors and prevent a catastrophe. Apoptosis, a form of programmed cell death, is a genetically regulated cell-suicide mechanism that is essential for our well-being. In this process, cells acquire the means of their own destruction in the form of an arsenal of deadly proteins, which they turn upon themselves. There are different pathways pro-apoptotic and pro-survival that crosstalk. In this work, we simulated the incremental integration of pro-apoptotic and pro-survival signalling pathways in a tuple spacebased bioinformatics platform, which provides a robust working environment for in silico experimentation, allowing us to work both separately and together on these pathways, including/removing deadly or regulatory proteins, and observing the consequences of such changes for the overall system behaviour.

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