alexa Integrative Bioinformatics Approaches to Analyze Molecular Events in Pluripotency
ISSN: 0974-8369

Biology and Medicine
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Integrative Bioinformatics Approaches to Analyze Molecular Events in Pluripotency

Priyanka Narad* and Upadhyaya KC

Amity Institute of Biotechnology, Amity University, Noida, Uttar Pradesh, India

*Corresponding Author:
Priyanka Narad
Amity Institute of Biotechnology
Amity University, Noida
Uttar Pradesh-201301, India
Tel: 09999302904
Email: [email protected]

Received Date: July 21, 2014; Accepted Date: August 23, 2014; Published Date:August 30, 2014

Citation: Priyanka Narad and Upadhyaya KC (2014) Integrative Bioinformatics Approaches to Analyze Molecular Events in Pluripotency. Biol Med 6:208. doi:10.4172/0974-8369.1000208

Copyright: © 2014 Narad P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Human embryonic stem cells (hESCs) have the capacity to proliferate almost indefinitely. Analysis of gene expression profiles of hESCs could offer an insight into the crucial genes concerned in maintaining pluripotency and the genes that may be involved in cell differentiation. Combining network and high throughput data enables to understand the role of epigenetic mechanisms, signalling pathways and transcription factors responsible in human pluripotency and screening of putative mechanistic relationships, validation of existing knowledge, yielding hypotheses, and suggestions for new experiments. Decoding the hub of factors and their associated interactions is an important beginning to understand the complexities associated with the hESCs and transfer the knowledge for creation of human induced pluripotent stem cells (hIPS). This review is aimed at increasing the elemental information of integrative bioinformatics approaches useful for studying self-renewal and differentiation processes using new holistic data on gene expression and epigenetic marks associated with cell pluripotency. Two basic approaches namely the representation as biological networks and semantic web technology have been described for the management of the ever increasing high throughput data. An integrated approach to disentangle the biological intricacies would be highly beneficial in the field of medical and health sciences

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords