alexa Interaction Studies of Sialic Acids with Model Receptors Contribute to Nanomedical Therapies
ISSN: 2329-6895

Journal of Neurological Disorders
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Review Article

Interaction Studies of Sialic Acids with Model Receptors Contribute to Nanomedical Therapies

Hans-Christian Siebert1, Ruiyan Zhang1,2, Axel Scheidig2, Thomas Eckert1,3, Hans Wienk4, Rolf Boelens4, Mehran Mahvash5, Athanasios K. Petridis6*, Roland Schauer7
1RI-B-NT – Research Institute of Bioinformatics and Nanotechnology, Schauenburgerstrasse 116, 24118 Kiel, Germany
2Zoologisches Institut – Strukturbiologie, Zentrum für Biochemie und Molekularbiologie, Christian-Albrechts-Universität Kiel, Am Botanischen Garten 1-9, 24118 Kiel, Germany
3Klinik für Geburtshilfe, Gynäkologie und Andrologie, Fachbereich Veterinärmedizin, Justus-Liebig-Universität Gießen, Frankfurter Str. 106, 35392 Gießen, Germany
4Bijvoet Center for Biomolecular Research, NMR Spectroscopy, Utrecht University, Padualaan 8, 3584 CH Utrecht, The Netherlands
5Neurochirurgische Abteilung, Klinikum Merheim, Köln, Germany
6Neurochirurgie, Klinikum Duisburg GmbH, Zu den Rehwiesen 9, 47055 Duisburg, Germany
7Biochemisches Institut, Universität Kiel, Olshausenstrasse 40, 24098 Kiel, Germany
Corresponding Author : Athanasios K. Petridis
Neurochirurgie, Klinikum Duisburg
GmbH, Zu den Rehwiesen 9
47055 Duisburg, Germany
Tel: 004915123465406
E-mail: [email protected]
Received February 05, 2015; Accepted February 26, 2015; Published February 28, 2015
Citation: Siebert HC, Zhang R, Scheidig A, Eckert T, Wienk H, et al. (2015) Interaction Studies of Sialic Acids with Model Receptors Contribute to Nanomedical Therapies. J Neurol Disord 3:212. doi: 10.4172/2329-6895.1000212
Copyright: © 2015 Siebert HC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Sialic acid supports nerve cell regeneration, differentiation and neuronal plasticity. Especially, polysialic acid (polySia) chains which are built up by α2,8-linked Neu5Ac Neu5Ac residues influence by their specific interactions with polySia receptors neuronal processes related to tumor spread and differentiation processes. With a combination of biophysical and biochemical methods including molecular modeling as described here it is possible to support cell biological experiments and in vivo studies on a nanoscale level. The submolecular analytical approaches which are directed to crucial functional groups focus on the potential therapeutic impact of sialic acids and in particular polySia. Such results are helpful for the development of new drugs which might have a high clinical relevance in respect to the therapy of various diseases correlated to neuronal regeneration, tumor spread and infections. It is not surprising that several diseases belonging to these different clinical fields (e.g. oncology, infection diseases, neuronal disorder) can be treated as indicated because sialic acids represent essential contact structures on numerous cell surfaces in dependence to their state of differentiation.

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