Interface Peptide Mimetics-Rationale and Application as Therapeutic Agents
School of Dentistry and Provaidya LLC, Indiana University– Purdue University at Indianapolis, Indianapolis, IN 46202, USA
- *Corresponding Author:
- Mythily Srinivasan, MS, PhD
Associate Professor, Oral Pathology
Radiology and Medicine, School of Dentistry
Indiana University, IN 46202, USA
E-mail: [email protected]
Received date: March 11, 2016; Accepted date: March 29, 2016; Published date: March 31, 2016
Citation: Srinivasan M (2016) Interface Peptide Mimetics-Rationale and Application as Therapeutic Agents. Med chem (Los Angeles) 6:189-194. doi:10.4172/2161-0444.1000344
Copyright: © 2016 Srinivasan M. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Biomolecular recognition via protein-protein interactions (PPI) is central to the signaling events in most physiological and pathological processes. Hence PPI are considered excellent targets for drug development. In recent years there is considerable interest in the design and development of peptide based drugs as antagonists or agonists of PPI. High potency, great selectivity and better safety profile are significant advantages of peptide therapeutics. The following is a brief review of the rationale and modifications in the design of peptide mimetics of PPI interface.