Interferon-Related Secretome Plays a Vital Role in PD-L1 Expression in the Tumor Microenvironment after Direct Interaction between Immune Cells and Tumor CellsYuan-Qin Yang1, Jonathan Howard DeLong2 and Kang-Jian Zhang1*
- *Corresponding Author:
- Kang-Jian Zhang
State Key Laboratory of Cell Biology
Institute of Biochemistry and Cell Biology
Shanghai Institutes for Biological Sciences
Chinese Academy of Sciences, 320 Yue-Yang Road
Shanghai 200031, PR China
E-mail: [email protected]
Received Date: June 27, 2016; Accepted Date: July 16, 2016; Published Date: July 18, 2016
Citation: Yang YQ, DeLong JH, Zhang KJ (2016) Interferon-Related Secretome Plays a Vital Role in PD-L1 Expression in the Tumor Microenvironment after Direct Interaction between Immune Cells and Tumor Cells. Single Cell Biol 5:146. doi: 10.4172/2168-9431.1000146
Copyright: © 2016 Yang YQ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
PD-L1, also known as CD274 or B7-H1, is a major immune checkpoint protein . The binding of PD-L1 to its receptor PD-1 induces an inhibitory signal that suppresses the immune response by several mechanisms such as inhibiting the proliferation of CD8+ T effector cells. This research has resulted in the development of promising clinical drugs such as anti-PD-1 antibodies including Keytruda (pembrolizumab, Merck), and Opdivo (nivolumab, BMS) as well as the anti-PD-L1 antibody Tecentriq (atezolizumab, Roche), and other peptides and small molecule inhibitors for cancer immunotherapy. However, the mechanism by which tumor cells expressing PD-L1 regulate the function of infiltrating immune cells within the tumor microenvironment is still not well understood.