alexa Interferon-Related Secretome Plays a Vital Role in PD-L1 Expression in the Tumor Microenvironment after Direct Interaction between Immune Cells and Tumor Cells
ISSN: 2168-9431

Single Cell Biology
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Commentary

Interferon-Related Secretome Plays a Vital Role in PD-L1 Expression in the Tumor Microenvironment after Direct Interaction between Immune Cells and Tumor Cells

Yuan-Qin Yang1, Jonathan Howard DeLong2 and Kang-Jian Zhang1*

1State Key Laboratory of Cell Biology, Shanghai Institute of Biochemistry and Cell Biology, Shanghai Institutes for Biological Sciences, Chinese Academy of Sciences, Shanghai 200031, PR China

2Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA 19104, USA

*Corresponding Author:
Kang-Jian Zhang
State Key Laboratory of Cell Biology
Institute of Biochemistry and Cell Biology
Shanghai Institutes for Biological Sciences
Chinese Academy of Sciences, 320 Yue-Yang Road
Shanghai 200031, PR China
Tel: 86-21-54921139
Fax: 86-21-54921126
E-mail: [email protected]

Received Date: June 27, 2016; Accepted Date: July 16, 2016; Published Date: July 18, 2016

Citation: Yang YQ, DeLong JH, Zhang KJ (2016) Interferon-Related Secretome Plays a Vital Role in PD-L1 Expression in the Tumor Microenvironment after Direct Interaction between Immune Cells and Tumor Cells. Single Cell Biol 5:146. doi: 10.4172/2168-9431.1000146

Copyright: © 2016 Yang YQ, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

PD-L1, also known as CD274 or B7-H1, is a major immune checkpoint protein . The binding of PD-L1 to its receptor PD-1 induces an inhibitory signal that suppresses the immune response by several mechanisms such as inhibiting the proliferation of CD8+ T effector cells. This research has resulted in the development of promising clinical drugs such as anti-PD-1 antibodies including Keytruda (pembrolizumab, Merck), and Opdivo (nivolumab, BMS) as well as the anti-PD-L1 antibody Tecentriq (atezolizumab, Roche), and other peptides and small molecule inhibitors for cancer immunotherapy. However, the mechanism by which tumor cells expressing PD-L1 regulate the function of infiltrating immune cells within the tumor microenvironment is still not well understood.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]icsonline.com

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords