Interleukin 23 P 19 Expression in Patients with Ulcerative Colitis and Its Relation to Disease Severity
- *Corresponding Author:
- Hanan Al-Saeid Al-Shenawy
Assistant professor in pathology department
Faculty of Medicine, Tanta University
25 Hamdy Gado street, Tanta, Egypt
Tel: 0020403296201, 00201201892237
E-mail: [email protected]
Received Date: July 18, 2014; Accepted Date: September 24, 2014; Published Date: September 26, 2014
Citation: Bassat HE, Ali LA, Yamany SE, Shenawy HA, Din RAA, et al. (2014) Interleukin 23 P 19 Expression in Patients with Ulcerative Colitis and Its Relation to Disease Severity. J Mol Biomark Diagn 5:191. doi:10.4172/2155-9929.1000191
Copyright: © 2014 Bassat HE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background and study aims: The purpose of this study is to determine whether mucosal expression of IL 23 p 19 has role in the pathogenesis of ulcerative colitis and its relation to disease severity.
Materials and methods: This study was carried out on 50 patients with ulcerative colitis and 10 normal individuals as control. They were divided into: Group I: 27 patients with mild to moderate disease. Group II: 23 patients with severe disease. Group III: 10 normal individuals. All patients and control were subjected to histopathological study, IL-23p19 immunohistochemical staining, IL-23R expression by flow cytometry and serum IL-23 by ELISA.
Results: There is significant increased in IL-23p19 gene and IL-23R in ulcerative colitis patients compared with control. Significant positive correlation was detected between increased expression of IL-23 p19 gene, IL-23R, high serum IL-23 and severity of the disease.
Conclusions: increased expression of IL-23 p19 is associated with ulcerative colitis and may indicate a role in its pathogenesis and that targeted therapy directed against IL-23 p19 may be effective in the treatment. Also increased expression of IL-23p19 gene and IL-23R with high serum IL-23 correlate positively with disease severity.