alexa Interleukin -7 (IL-7) Increases Metabolic Thymic and CNS Activity
ISSN: 2157-7013

Journal of Cell Science & Therapy
Open Access

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Letter to Editor

Interleukin -7 (IL-7) Increases Metabolic Thymic and CNS Activity

Isabelle Magalhaes1, Alejandro Sánchez-Crespo2, Marco Pagani2,3, Nalini K. Vudattu4, Gudrun Nylen5, Christer Halldin5, Mats Spångberg6, Stig A. Larsson2, Balázs Gulyás5 and Markus J. Maeurer1,7*

1Karolinska Institute, Department of Microbiology, Tumor and Cell Biology (MTC), Stockholm, Sweden

2Karolinska University Hospital, Departmentof Nuclear Medicine, Stockholm, Sweden

3Institute of Cognitive Sciences and Technologies (CNR), Rome, Italy

4Centre for Immunology and Inflammatory Diseases, Massachusetts General Hospital, Charlestown, Massachusetts, USA

5Karolinska Institute, Department of Clinical Neuroscience, Psychiatry Section, Stockholm, Sweden

6The Swedish Institute for Infectious Disease Control, Solna, Sweden

7CAST, Karolinska Hospital, Stockholm, Sweden

*Corresponding Author:
Markus J. Maeurer
Department of Microbiology and Tumor and Cell Biology (MTC) and CAST
Karolinska Hospital, NobelsVäg 16, SE-171 82 Stockholm, Sweden
Tel: +46 (0)708628566
E-mail: [email protected]

Received date: May 02, 2012; Accepted date: June 06, 2012; Published date: June 08, 2012

Citation: Magalhaes I, Sánchez-Crespo A, Pagani M, Vudattu NK, Nylen G, et al. (2012) Interleukin -7 (IL-7) Increases Metabolic Thymic and CNS Activity. J Cell Sci Ther 3:127. doi: 10.4172/2157-7013.1000127

Copyright: © 2012 Magalhaes I, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Interleukin-7 (IL-7) is currently used in a number of clinical trials in humans, including treatment trials for patients with HIV or HCV infection. We would like to draw the attention concerning the impact of IL-7 on the central nervous system (CNS), since most clinical evaluations may not include detailed CNS examination, e.g. Positron Emission Tomography - Computed Tomography (PET-CT) or the evaluation of changes in complex behavior patterns. Increased IL-7-mediated thymic activity demonstrates that viable thymic tissue can be activated in younger individuals; we observed also increased metabolic activity in bone marrow. This has also been observed in clinical studies with individuals who received 30 and 60 μg IL-7 /kg bodyweight leading to increased B-cell progenitors, yet without increased numbers of peripheral B-cells. In summary, our results suggest that IL-7 is able to activate thymic tissue, if functionally receptive. Increased CNS metabolic activity after IL-7 application suggests to monitor the effects of IL-7 for more complex neurological functions and the CNS-metabolic axis in more controlled, comprehensive study settings. It also prepares to consider effects of cytokines on networks of non-lymphoid cells and tissues in patients enrolled in IL-7 trials.

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