Objective: Benign migratory glossitis is a immunologic-psychologic disease with unknown etiology. Aim of this study is evaluation of salivary IL-1 and Il-8 levels in these patients. Study Design: A case-control study was performed on 170 participants (85 with BMG, 85 controls). Unstimulated whole saliva was collected, and interleukin 8 (IL-8) and interleukin 1(IL-1) concentrations were measured. Anxiety level was measured using psychologic and physiologic testing instruments. An independent t test and a Pearson correlation analysis were performed with SPSS. Results: There was a significant difference between the 2 groups regarding the salivary concentrations of IL8 (P ≤ .006) and IL-1 (P ≤ .002). The concentration of salivary cortisol and state and trait anxiety levels in the BMG group were significantly higher than those in the control group (P ≤ .001). Conclusions: Immunologic and psychologic parameters appear associated with BMG and may constitute risk factors of this condition.