alexa Interleukin-2 Receptor α-chain (CD25) Expression in Acute Myeloid Leukemia | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Commentary

Interleukin-2 Receptor α-chain (CD25) Expression in Acute Myeloid Leukemia

Kazunori Nakase1,3*, Kenkichi Kita2 and Naoyuki Katayama3

1Cancer Center, Mie University Hospital, Tsu, Japan

2Department of Internal Medicine, Japan Baptist Hospital, Kyoto, Japan

3Department of Hematology and Oncology, Mie University Graduate School of Medicine, Tsu, Japan

*Corresponding Author:
Kazunori Nakase
Cancer Center, Mie University Hospital
2-174 Edobashi, Tsu
Mie 514-8507, Japan
Tel: 81592315296
Fax: 81592315348
E-mail: [email protected]

Received date: May 26, 2016; Accepted date: August 05, 2016; Published date: August 09, 2016

Citation: Nakase K, Kita K, Katayama N (2016) Interleukin-2 Receptor α-chain (CD25) Expression in Acute Myeloid Leukemia. J Clin Cell Immunol 7:444. doi: 10.4172/2155-9899.1000444

Copyright: © 2016 Nakase K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Recent studies have shown that cytokine/cytokine receptor systems affect leukemic cell biology and clinical behavior of leukemic patients. Among various cytokine receptors, only interleukin-2 receptor α-chain (IL-2Rα, CD25) expression predicts a poor prognosis of patients (≤ 60 years old) with acute myeloid leukemia (AML). Even in prognostic analyses including unfavorable surface markers and cytogenetics, IL-2Rα is recognized to be an independent adverse indicator in such patients. Assessment of the presence of IL-2Rα should be essential to make therapeutic risk classification of AML patients in a future. However, as the lack of IL-2 responsiveness is observed in AML cells, further investigations are required to clarify the mechanism why IL-2Rα(+) AML patients have a dismal clinical outcome

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