alexa Interleukin-6 as an Independent Predictor of Future Cardiovascular Events in Patients with Type-2 Diabetes without Structural Heart Disease
ISSN: 2155-9880

Journal of Clinical & Experimental Cardiology
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Research Article

Interleukin-6 as an Independent Predictor of Future Cardiovascular Events in Patients with Type-2 Diabetes without Structural Heart Disease

Tetsuji Shinohara1*, Naohiko Takahashi2, Norihiro Okada1, Reika Ayabe1, Hidekazu Kondo1, Kunio Yufu2, Mikiko Nakagawa2,
Masahide Hara1 and Tetsunori Saikawa2
1Department of Internal Medicine, Faculty of Medicine, Oita University, Oita, Japan
2Department of Laboratory Examination and Diagnostics, Faculty of Medicine, Oita University, Oita, Japan
Corresponding Author : Tetsuji Shinohara, MD, Ph.D
1-1 Idaigaoka, Hasamamachi, Yuhu, Oita, Japan
Tel: +81-97-586-5793
Fax: +81-97-549-4480
E-mail: [email protected]
Received July 02, 2012; Accepted August 07, 2012; Published August 10, 2012
Citation: Shinohara T, Takahashi N, Okada N, Ayabe R, Kondo H, et al. (2012) Interleukin-6 as an Independent Predictor of Future Cardiovascular Events in Patients with Type-2 Diabetes without Structural Heart Disease. J Clin Exp Cardiolog 3:209. doi:10.4172/2155-9880.1000209
Copyright: © 2012 Shinohara T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background: An increased serum interleukin-6 (IL-6) level is associated with a risk of cardiovascular disease. Elevated IL-6 levels are also involved in the pathogenesis of insulin resistance and can predict the development of type-2 diabetes. We tested the hypothesis that elevated IL-6 levels can predict the incidence of cardiovascular events in type-2 diabetes. Methods: Eighty-two patients with type-2 diabetes without structural heart disease (48 males; 60 ± 12 years). The initial onset of a major adverse cardiovascular event was investigated. Results: During a mean of 3.4 ± 2.0 years of follow-up, 11 patients developed cardiovascular events (3 cardiovascular deaths, 2 non-fatal myocardial infarctions, 2 coronary revascularizations, and 4 strokes). Univariate analyses revealed that elevated IL-6 level, fasting immunoreactive insulin level, and the HOMA-R were associated with cardiovascular events. Based on multivariate analyses, elevated IL-6 levels independently predicted the incidence of cardiovascular events (HR 1.17, 95% CI 1.04–1.31, P=0.015). Kaplan–Meier curves revealed that patients with a high IL-6 concentration (>2.6 pg/mL) had a higher incidence of cardiovascular events than those with non-high IL-6 concentration (≤2.6 pg/mL, P=0.031). Conclusions: These results suggest that measurement of serum IL-6 concentration is a useful tool to identify high-risk patients for cardiovascular events in type-2 diabetes.

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