alexa Interleukin-6 Cytokine: A Multifunctional Glycoprotein for Cancer | OMICS International | Abstract
ISSN: 1745-7580

Immunome Research
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Review Article

Interleukin-6 Cytokine: A Multifunctional Glycoprotein for Cancer

Paul Zarogoulidis1,2*, Lonny Yarmus3, Kaid Darwiche2, Robert Walter2,4, Haidong Huang5, Zhigang Li6, Bojan Zaric7, Kosmas Tsakiridis8 and Konstantinos Zarogoulidis1

1Pulmonary Department-Oncology Unit, ``G. Papanikolaou`` General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece

2Department of Interventional Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital, University Duisburg-Essen, Essen, Germany

3Division of Pulmonary and Critical Care Medicine, Sheikh Zayed Cardiovascular & Critical Care Tower, Johns Hopkins University, Baltimore, USA

4Institute of Pathology and Neuropathology, University Hospital Essen, University Duisburg-Essen, Essen, Germany

5Department of Respiratory Diseases Shanghai Hospital, II Military University Hospital, Shanghai, China

6Department of Thoracic & Cardiac Surgery, Changhai Hospital, The Second Military Medical University, Shanghai, China

7Institute for Pulmonary Diseases of Vojvodina, Clinic for Thoracic Oncology, Faculty of Medicine, University of Novi Sad, Serbia

8Cardiothoracic Surgery Department, ``Saint Luke`` Private Hospital of Health Excellence, Thessaloniki, Greece

Corresponding Author:
Paul Zarogoulidis, M.D, Ph.D
Pulmonary Department-Oncology Unit
“G. Papanikolaou” General Hospital
Aristotle University of Thessaloniki
Thessaloniki, Greece
Tel: 00306977271974
Fax: 0030-231-099-2432
E-mail: [email protected]

Received date: July 17, 2013; Accepted date: August 07, 2013; Published date: August 12, 2013

Citation: Zarogoulidis P, Yarmus L, Darwiche K, Walter R, Huang H, et al. (2013) Interleukin-6 Cytokine: A Multifunctional Glycoprotein for Cancer. Immunome Res 9:062. doi: 10.4172/2090-5009.1000062

Copyright: © 2013 Zarogoulidis P, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Interleukin 6 is a multifunctional cytokine. Its increased levels have been associated with elevated cancer risk, and also these levels have been found to be a prognostic factor for several cancer types. In addition, increased levels have been found in coronary heart disease, insulin resistant patients, advance stage cancer patients, atopy/asthma and in patients with blood circulating micrometastasis. Additionally several studies with different types of cancers have been performed to identify the correlation between interleukin-6 levels, stage, treatment response and severity of symptoms. The influence of interleukin-6 is performed mainly through the janus kinase-signal transducer and activator of transcription-zinc finger protein 1-2 signaling pathway. As a result, the increased levels of interleukin-6 are responsible for enhanced neo-angiogenesis, inhibition of cancer cell apoptosis and deregulation of the control mechanisms in the microenvironment. In addition, increased levels of inteleukin-6 have been found to increase the production of collagen and a-actin which induce interstitial lung disease. In the current mini review we will present information regarding the interleukin-6 and published results in several cancer studies and finally we will comment in future treatment approaches blocking this cytokine in cancer patients.

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