alexa Interstitial Flow in Cancerous Tissue: Effect of Considering Remodeled Capillary Network | OMICS International
ISSN: 2157-7552

Journal of Tissue Science & Engineering
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Special Issue Article

Interstitial Flow in Cancerous Tissue: Effect of Considering Remodeled Capillary Network

M Sefidgar1, M Soltani1,2,3*, H Bazmara1, M Mousavi1, M Bazargan1 and A Elkamel2
1Mechanical Engineering, K. N. Toosi University of Technology, Tehran, Iran
2Waterloo Institute for Nanotechnology, University of Waterloo, Waterloo, ON, Canada
3Division of Nuclear Medicine, Department of Radiology and Radiological Science, Johns Hopkins University, School of Medicine, MD, USA
Corresponding Author : M Soltani
Division of Nuclear Medicine, Department of Radiology and Radiological Science
Johns Hopkins University, School of Medicine, MD, USA
Tel: 410-614-1738
E-mail: [email protected], [email protected](or) [email protected]
Received May 03, 2013; Accepted January 22, 2014; Published January 24, 2014
Citation: Sefidgar M, Soltani M, Bazmara H, Mousavi M, Bazargan M, et al. Interstitial Flow in Cancerous Tissue: Effect of Considering Remodeled Capillary Network. J Tissue Sci Eng S4:003. doi:10.4172/2157-7552.S4-003
Copyright: © 2014 Sefidgar M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Interstitial fluid flow has been studied by many cancer researchers for investigation of how interstitial flow can
affect drug delivery. This paper couples blood flow through a capillary network induced by tumor angiogenesis and
fluid flow in interstitium and investigates the effects of consideration of a remodeled network and adaptability of
capillary on interstitial flow. Two approaches are studied for showing the remodeling effects. In the first approach,
the capillary network is presumed to have capillary with constant diameter. For the second approach, the adaptable
capillaries are assumed in which the metabolic and hemodynamic stimuli changes capillary’s diameter based on
sending signals to capillary. Numerical results show that the intravascular pressure has more uniform distribution
along the network and capillary diameter has greater value in the network. The prediction of interstitial pressure for
the second approach shows higher values compared to the first approach. Results from interstitial flow and blood
flow distribution in normal and cancerous tissues have beneficial information about prediction of successive drug
delivery.

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