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Interventional Oncology - Avoiding Common Pitfalls to Reduce Toxicity in Hepatic Radioembolization | OMICS International | Abstract
ISSN: 2155-9619

Journal of Nuclear Medicine & Radiation Therapy
Open Access

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Special Issue Article

Interventional Oncology - Avoiding Common Pitfalls to Reduce Toxicity in Hepatic Radioembolization

David M Liu1,2*, David Cade3, Darren Klass1, Christopher Loh2, Justin P McWilliams2 and David Valenti4

1Department of Radiology, Vancouver General Hospital, University of British Columbia, Vancouver, BC, Canada

2Angio/interventional Section, UCLA Department of Radiological Sciences, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA

3Sirtex Medical Limited, Sydney, Australia

4Division of Interventional Radiology, Department of Radiology, McGill University Health Centre, Montreal, QC, Canada

*Corresponding Author:
David Liu
855 W 12th Ave, JP Pavilion G873, Vancouver
British Columbia, Canada, V5Z 1M9
E-mail: [email protected]

Received date: April 26, 2011; Accepted date: May 26, 2011; Published date: June 15, 2011

Citation: Liu DM (2011) Interventional Oncology - Avoiding Common Pitfalls to Reduce Toxicity in Hepatic Radioembolization. J Nucl Med Radiat Ther 2:106. doi: 10.4172/2155-9619.1000106

Copyright: © 2011 Liu DM. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Within the setting of hepatic neoplasia [primary and secondary], selective internal radiation therapy [SIRT], also known as radioembolization has become an accepted procedure, incorporated into the armamentarium of multidisciplinary oncologic care. The procedure itself requires understanding of mesenteric anatomy, tumor vascular patterns, liver metabolism, and chemotherapy. Given the complex nature of the treatment, unique toxicities, and complications may develop from multiple etiologies. Reduction of toxicities and complications as they relate to this procedure can be stratified into two broad categories: factors involving vascularity/vascularization, and factors involving compromise to the underlying liver parenchyma. The purpose of this manuscript is to provide the reader with a systematic review of the most commonly presented toxicities, their etiologies, prevention strategies, and suggested therapeutic options in a practical, and concise manner. A brief discussion on the common misconceptions regarding toxicities will be included.

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