alexa Interventions to Enhance Adherence to Guideline Recommendations in Secondary and Tertiary Prevention of Heart Failure: A Systematic Review
ISSN: 2167-0870

Journal of Clinical Trials
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Protocol

Interventions to Enhance Adherence to Guideline Recommendations in Secondary and Tertiary Prevention of Heart Failure: A Systematic Review

Susanne Unverzagt1*, Andreas Klement2, Gabriele Meyer3 and Roland Prondzinsky4
1Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany
2Section of General Practice, Institute of Medical Epidemiology, Biostatistics and Informatics, Martin-Luther-University Halle-Wittenberg, Halle, Germany
3Institute for Health and Nursing Science, Martin-Luther-University Halle-Wittenberg, Halle, Germany
4Cardiology/Intensive Care Medicine, Carl von Basedow Klinikum Merseburg, Merseburg, Germany
Corresponding Author : Susanne Unverzagt, PhD
Institute of Medical Epidemiology
Biostatistics and Informatics
Martin-Luther-University Halle-Wittenberg
06097 Halle (Saale), Germany
Tel: +49-34-5557-4486
Fax: +49-34-5557-3580
E-mail: [email protected]
Received August 12, 2014; Accepted October 31, 2014; Published November 03, 2014
Citation: Unverzagt S, Klement A, Meyer G, Prondzinsky R (2014) Interventions to Enhance Adherence to Guideline Recommendations in Secondary and Tertiary Prevention of Heart Failure: A Systematic Review. J Clin Trials 4:192. doi:10.4172/2167-0870.1000192
Copyright: © 2014 Unverzagt S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Background: Heart Failure (HF) is a major clinical and public health problem with strong implications for quality of life and high socioeconomic impact due to costs of treatment. Patients being treated according to the present recommendations show improved survival and lower rehospitalization rates, but poor adherence is considered to be a critical barrier for treatment success. Therefore, we want to investigate interventions aimed at improving adherence of patients to recommendations on HF, e.g. how do physicians approach their patients’ problems, provide information and involve individual values and preferences in the process of decision making? To date, many randomized trials have investigated interventions to reduce barriers for adherence, but a systematic review of these interventions is needed.
Methods: This systematic review should evaluate the efficacy and effectiveness of interventions to enhance patient adherence to guideline recommendations in secondary and tertiary prevention of HF. Methodology follows the recommendations of the Cochrane Handbook for Systematic Reviews of Interventions. We will include only randomized controlled trials and classify interventions according to their active component as interventions concerning the provider, patient education, and patient reminder, promotion of patients’ self-management, organizational change or technical solutions. The primary outcome measure is patient adherence; important patient outcomes such as quality of life, mortality, morbidity, hospital admissions and readmissions, days in hospital, and costs are added as secondary
outcomes. A random-effects meta-regression model will be used to simultaneously assess the influence of different strategies on patient adherence. Analyses on heterogeneity will include pre-defined methodological and clinical sources of heterogeneity.
Conclusion: This systematic review should identify major components of successful interventions aimed to foster the therapeutic adherence and/or self-managing abilities of patients. Without appropriate strategies for promoting adherence the transfer of guideline recommendations into daily practice is hindered by many obstacles that reduce the desired health outcome.
Systematic review registration: PROSPERO CRD42014009477.

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